{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:00Z","timestamp":1787237700053,"version":"build-2736575974"},"reference-count":47,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>\n                    Nonalcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. Coagonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) are under clinical investigation for the treatment of obesity and type 2 diabetes. In this study, we have demonstrated the effect of a balanced coagonist in the treatment of NAFLD using mouse models. GLP-1R agonist exendin-4, glucagon, and coagonist (Aib2 C24 chimera2) were administered to C57BL6\/J mice, in which NAFLD was induced by carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) treatment after high-fat diet (HFD) feeding, and choline-deficient, L-amino-acid-defined HFD (CDAHFD) feeding. Repeated dose administration of coagonist significantly attenuated liver inflammation and steatosis induced by acute and long-term treatment with CCl\n                    <jats:sub>4<\/jats:sub>\n                    in HFD-fed mice. Coagonist markedly attenuated the CDAHFD-induced expression of TIMP-1, MMP-9, TNF-\u03b1, MCP-1, COL1A1, and \u03b1-SMA. It also inhibited progression of hepatic steatosis and fibrosis in mice. Exendin-4 was better than glucagon, but coagonist was most effective in reduction of hepatic inflammation as well as steatosis. Coagonist of GLP-1R and GCGR improved NAFLD in C57BL6\/J mice. This effect is mediated by reduction in lipotoxicity and inflammation in liver.\n                  <\/jats:p>","DOI":"10.1139\/cjpp-2017-0683","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T17:37:55Z","timestamp":1517938675000},"page":"587-596","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates nonalcoholic fatty liver disease"],"prefix":"10.1139","volume":"96","author":[{"given":"Vishal","family":"Patel","sequence":"first","affiliation":[{"name":"Zydus Research Centre, Cadila Healthcare Limited, Sarkhej-Bavla N.H. 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