{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:37:23Z","timestamp":1788910643840,"version":"build-2803163510"},"reference-count":37,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>This study aimed to validate whether macrophage polarization imbalance and abnormal cytokines production occurred in pregnancy-induced hypertension (PIH) patients. PIH women (n = 26) were enrolled and the level of biochemical parameters were determined. The percentage of CD86- and CD163-positive cells, representing M1 and M2 macrophages, were determined by flow cytometry. The concentrations of cytokines (TNF-\u03b1, IL-1\u03b2, IL-4, IL-13, and IL-10) were determined using enzyme-linked immunosorbent assay kit. THP-1 cells were incubated with 10% serum from PIH and control groups, and then macrophage polarization and cytokines production were analyzed. The levels of high-density lipoprotein cholesterol and apolipoprotein A1 were significantly lower, and the levels of fasting blood glucose, total cholesterol, triacylglycerol, low-density lipoprotein cholesterol, apolipoprotein B, and lipoprotein a were significantly higher in the PIH group than that in the control group. The PIH group contained a significant higher percentage of CD86-positive cells (M1) and a significant lower percentage of CD163-positive cells (M2), representing higher M1\/M2 ratio, than the control group. The PIH group expressed higher concentrations of TNF-\u03b1 and IL-1\u03b2, and expressed lower concentrations of IL-4, IL-10, and IL-13 than the control group. The in vitro experiment also showed macrophage polarization imbalance and abnormal cytokines production in THP-1 cells treated with PIH serum as compared with that treated with control serum. Macrophage polarization imbalance and abnormal cytokines production occurred in PIH patients and in THP-1 cells treated with PIH serum.<\/jats:p>","DOI":"10.1139\/cjpp-2017-0694","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T09:42:45Z","timestamp":1530697365000},"page":"922-928","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Macrophage M1\/M2 polarization in patients with pregnancy-induced hypertension"],"prefix":"10.1139","volume":"96","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310001, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Hangzhou Women\u2019s Hospital, Hangzhou, 310008, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Banan People\u2019s Hospital of Chongqing, Chongqing, 401320, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310003, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"issue":"2","key":"refg1\/ref1","first-page":"390","volume":"1","author":"Anjana S.","year":"2010","journal-title":"Int. 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