{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:04:02Z","timestamp":1788239042594,"version":"build-2803163510"},"reference-count":18,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p> The hybrid Norwood operation is performed to treat hypoplastic left heart syndrome. Distal arch obstruction may compromise flow to the brain. In a variant of this procedure, a synthetic graft (reverse Blalock\u2013Taussig shunt) is placed between the pulmonary trunk and innominate artery to improve upper torso blood flow. Thrombi originating in the graft may embolize to the brain. In this study, we used computational fluid dynamics and particle tracking to investigate the patterns of particle embolization as a function of the anatomic position of the reverse Blalock\u2013Taussig shunt. The degree of distal arch obstruction and position of particle origin influence embolization probabilities to the cerebral arteries. Cerebral embolization probabilities can be reduced by as much as 20% by optimizing graft position, for a given arch geometry, degree of distal arch obstruction, and particle origin. There is a tradeoff, however, between cerebral pulmonary and coronary embolization probabilities. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0002","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T21:35:15Z","timestamp":1527024915000},"page":"690-700","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Patient-specific multiscale computational fluid dynamics assessment of embolization rates in the hybrid Norwood: effects of size and placement of the reverse Blalock\u2013Taussig shunt"],"prefix":"10.1139","volume":"96","author":[{"given":"Ray","family":"Prather","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Central Florida, 4000 Central Florida Blvd., Orlando, FL 32816, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Seligson","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Central Florida, 4000 Central Florida Blvd., Orlando, FL 32816, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Central Florida, 4000 Central Florida Blvd., Orlando, FL 32816, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Divo","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Embry-Riddle Aeronautical University, 600 South Clyde Morris Blvd., Daytona Beach, FL 32114, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Kassab","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, University of Central Florida, 4000 Central Florida Blvd., Orlando, FL 32816, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"DeCampli","sequence":"additional","affiliation":[{"name":"Arnold Palmer Children\u2019s Hospital, 1222 S. Orange Ave., Orlando, FL 32806, USA."},{"name":"College of Medicine, University of Central Florida, 6850 Lake Nona Blvd, Orlando, FL 32827, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.07.053"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.01.038"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000530"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.04.078"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.06.010"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.04.127"},{"key":"refg6\/ref6","unstructured":"Ceballos, A. 2015. A coupled CFD-lumped parameter model of the human circulation: elucidating the hemodynamics of the hybrid Norwood palliative treatment and effects of the reverse Blalock\u2013Taussig shunt placement and diameter. Ph.D. dissertation, University of Central Florida, Orlando, Fla."},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.06.043"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1080\/17415977.2012.667092"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.009"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1370-z"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.010769"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1097\/01.mat.0000180353.12963.f2"},{"key":"refg16\/ref16","unstructured":"Prather, R. 2015. A multi-scale CFD analysis of patient-specific geometries to tailor LVAD cannula implantation under pulsatile flow conditions: an investigation aimed at reducing stroke incidence in LVADs. M.S. thesis, University of Central Florida, Orlando, Fla."},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1108\/HFF-10-2016-0378"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182456d46"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-012-0579-3"},{"key":"refg20\/ref20","unstructured":"Seligson, J. 2017. Computational fluid dynamics study of thromboembolism as a function of shunt size and placement in the hybrid Norwood palliative treatment of hypoplastic left heart syndrome. M.S. thesis, University of Central Florida, Orlando, Fla."}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2018-0002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2018-0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:29:29Z","timestamp":1751470169000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2018-0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1139\/cjpp-2018-0002"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2018-0002","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2018-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}