{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:43Z","timestamp":1759336303637,"version":"3.41.0"},"reference-count":63,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p> Le calcium et le magn\u00e9sium sont des ions divalents multipotents importants pour le m\u00e9tabolisme, l\u2019excitabilit\u00e9, et la plasticit\u00e9 de la n\u00e9vroglie. En raison de leurs multiples propri\u00e9t\u00e9s, leur carence provoque des processus c\u00e9r\u00e9braux complexes menant \u00e0 des aberrations aig\u00fces voire durables au niveau de l\u2019excitabilit\u00e9 et des r\u00e9seaux neuronaux. Ces ions sont habituellement prescrits dans des contextes cliniques d\u2019hyperexcitabilit\u00e9 neuronale comme la pr\u00e9\u00e9clampsie et le stress chronique. Notre objectif \u00e9tait d\u2019\u00e9valuer si le magn\u00e9sium \u00e0 20 mg\/kg et le calcium \u00e0 100 mg\/kg pouvaient am\u00e9liorer le pronostic mn\u00e9sique dans le mod\u00e8le ka\u00efnique d\u2019\u00e9pilepsie m\u00e9siale temporale chez les souris. Les animaux furent organis\u00e9s en six groupes : groupe t\u00e9moin (sans ka\u00efnate), groupe de r\u00e9f\u00e9rence sans administration d\u2019ions (GR), groupes trait\u00e9s au magn\u00e9sium ou au calcium d\u00e8s le troisi\u00e8me jour (respectivement G1m, G1c), groupes trait\u00e9s au magn\u00e9sium ou au calcium \u00e0 partir de la troisi\u00e8me semaine (respectivement G2m, G2c). Les souris trait\u00e9es ont toutes pr\u00e9sent\u00e9 de meilleures performances que les souris GR, mais le magn\u00e9sium \u00e9tait plus efficace. La m\u00e9moire (court terme\u2013long terme) \u00e9tait touch\u00e9e diff\u00e9remment par le ka\u00efnate ou am\u00e9lior\u00e9e par le magn\u00e9sium et le calcium. De plus, le magn\u00e9sium a d\u00e9montr\u00e9 un effet th\u00e9rapeutique croissant avec le temps alors que le calcium avait un effet aigu qui semblait se d\u00e9grader pour le groupe G1c qui re\u00e7ut pr\u00e9cocement du calcium. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0020","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T21:44:22Z","timestamp":1533764662000},"page":"1132-1144","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Le magn\u00e9sium et le calcium r\u00e9duisent la s\u00e9v\u00e9rit\u00e9 des troubles de la m\u00e9moire spatiale pour le mod\u00e8le ka\u00efnique d\u2019\u00e9pilepsie m\u00e9siale temporale chez la souris"],"prefix":"10.1139","volume":"96","author":[{"given":"D\u00e8nahin Hinnoutondji","family":"Toffa","sequence":"first","affiliation":[{"name":"Neurologie, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H2X 0C1, 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