{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:48:01Z","timestamp":1760784481483,"version":"3.41.0"},"reference-count":45,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p> The present study was designed to ascertain the effects of 3 diets with different omega-3\/6 fatty acid ratios on infarct size and the modifications that these diets induce in the lipid composition of cardiac tissue. Sprague-Dawley rats were fed omega-3\/6 fatty acid diets with 1:1, 1:5, or 1:20 ratios for at least 10 days, followed by occlusion of the left anterior descending artery for 40 min and 24 h of reperfusion. Infarct size was significantly smaller in the 1:1 group than in the other groups. Significantly higher concentrations of the omega-3 fatty acids eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid were found in the 1:1 group than in the other groups. Omega-6 polyunsaturated fatty acid levels were similar between groups, although they were higher in the 1:5 and 1:20 groups than in the 1:1 group. Margaric acid concentrations were higher in the 1:1 group than in the other groups. Docosahexaenoic acid levels in cardiac tissue and infarct size were significantly correlated with no other significant links being apparent. The present study indicated that a 1:1 omega-3\/6 fatty acid ratio protected against ischemia and was associated with increased omega-3 fatty acid composition of cardiac tissue. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0043","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T21:34:51Z","timestamp":1527543291000},"page":"916-921","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["A high omega-3 fatty acid diet rapidly changes the lipid composition of cardiac tissue and results in cardioprotection"],"prefix":"10.1139","volume":"96","author":[{"given":"M\u00e9lissa","family":"Desnoyers","sequence":"first","affiliation":[{"name":"CIUSSS du nord de l\u2019\u00eele de Montr\u00e9al, H\u00f4pital Sacr\u00e9-C\u0153ur, Montr\u00e9al, QC H4J 1C5, Canada."},{"name":"D\u00e9partement de pharmacologie et de physiologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Gilbert","sequence":"additional","affiliation":[{"name":"CIUSSS du nord de l\u2019\u00eele de Montr\u00e9al, H\u00f4pital Sacr\u00e9-C\u0153ur, Montr\u00e9al, QC H4J 1C5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ness","family":"Madingou","sequence":"additional","affiliation":[{"name":"CIUSSS du nord de l\u2019\u00eele de Montr\u00e9al, H\u00f4pital Sacr\u00e9-C\u0153ur, Montr\u00e9al, QC H4J 1C5, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Andr\u00e9","family":"Gagn\u00e9","sequence":"additional","affiliation":[{"name":"CIUSSS du nord de l\u2019\u00eele de Montr\u00e9al, H\u00f4pital Sacr\u00e9-C\u0153ur, Montr\u00e9al, QC H4J 1C5, Canada."},{"name":"D\u00e9partement de pharmacologie et de physiologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Daneault","sequence":"additional","affiliation":[{"name":"Institut de cardiologie de Montr\u00e9al, Montr\u00e9al, QC H1T 1C8, Canada."},{"name":"D\u00e9partement de nutrition, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1A8, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Des Rosiers","sequence":"additional","affiliation":[{"name":"Institut de cardiologie de Montr\u00e9al, Montr\u00e9al, QC H1T 1C8, Canada."},{"name":"D\u00e9partement de nutrition, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1A8, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Rousseau","sequence":"additional","affiliation":[{"name":"CIUSSS du nord de l\u2019\u00eele de Montr\u00e9al, H\u00f4pital Sacr\u00e9-C\u0153ur, Montr\u00e9al, QC H4J 1C5, Canada."},{"name":"D\u00e9partement de pharmacologie et de physiologie, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3J7, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.10.1902"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.12.004"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.04.077"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203859"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-006-6313-6"},{"issue":"8666","key":"refg6\/ref6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(89)90828-3","volume":"2","author":"Burr M.L.","year":"1989","journal-title":"Lancet"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1788"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000335820"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.119271"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.3390\/nu7105404"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.12.016"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07072-5"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.024"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.771881"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002137.pub2"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90431-3"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.081133"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.170605"},{"issue":"12","key":"refg18\/ref18","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0022-2275(20)34457-6","volume":"25","author":"Lepage G.","year":"1984","journal-title":"J. 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