{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:07:54Z","timestamp":1751515674839,"version":"3.41.0"},"reference-count":50,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p> Volume overload is a common phenomenon in patients with chronic kidney disease that is associated with cardiovascular risk factors. However, its contribution to the development of adverse cardiovascular outcomes in those patients is not fully understood. Thus, the present work investigated the effect of salt-induced volume overload on cardiac functions and geometry in a rat model of chronic kidney disease. Thirty adult male Sprague\u2013Dawley rats were randomly divided. One set of animals received a sham operation, while another set of animals underwent uninephrectomy. Rats were then fed either a normal-salt (0.4%) or high-salt (8.0%) diet for 6 weeks. The salt-loaded, uninephrectomized rats were treated with indapamide (3 mg\u00b7kg<jats:sup>\u20131<\/jats:sup>\u00b7day<jats:sup>\u20131<\/jats:sup>, orally) for 6 weeks. We found that uninephrectomized rats subjected to a high-salt diet (8.0%) for 6 weeks presented with hypertension, proteinuria, decreased renal Klotho expression, and deterioration in cardiac hemodynamics and histology. Echocardiography to assess cardiac function showed that ejection fraction and fractional shortening were positively correlated with relative renal Klotho expression. In conclusion, salt-induced volume overload in a rat model of chronic kidney disease has an adverse cardiovascular outcome and is associated with inflammatory activation and decrease in renal Klotho expression. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0070","type":"journal-article","created":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T21:33:56Z","timestamp":1533418436000},"page":"1197-1208","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Contribution of volume overload to progression of cardiovascular disease in a rat model of chronic kidney disease"],"prefix":"10.1139","volume":"96","author":[{"given":"Manal Moustafa","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Cairo University, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Mohammed","family":"Shamseldeen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Cairo University, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Ahmed","family":"Rashed","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal Elham","family":"Fares","sequence":"additional","affiliation":[{"name":"Department of Medical Histology, Faculty of Medicine, Cairo University, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Shamaa","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Cairo University, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa Mostafa","family":"Gharib","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2009.32"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2004.04.003"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164680"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.1.R1"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.886473"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803223105"},{"issue":"8","key":"refg8\/ref8","first-page":"391","volume":"44","author":"Chan Y.H.","year":"2003","journal-title":"Singapore Med. 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