{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:25:50Z","timestamp":1759616750667,"version":"3.41.0"},"reference-count":35,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p> The aim of this study was to assess the impact of atorvastatin and simvastatin on myocardial contractility during the different degrees of hyperhomocysteinemia (HHcy) in rats. Study was conducted on adult male Wistar albino rats (n = 90; 4 weeks old; 100 \u00b1 15 g body mass) in which HHcy was achieved by dietary manipulation. Animals were exposed to pharmacology treatment with atorvastatin in dose of 3 mg\/kg per day i.p. or simvastatin in dose of 5 mg\/kg per day i.p. at the same time every day, according to equivalent therapeutic doses of these statins (10 mg atorvastatin = 20 mg simvastatin). After the dietary manipulation and pharmacological treatment and confirmation of HHcy, all animals were sacrificed, hearts were isolated, and cardiac function was tested according to the Langendorff technique. Size of recovery of maximum rate of left ventricular development (dp\/dt<jats:sub>max<\/jats:sub>), minimum rate of left ventricular development (dp\/dt<jats:sub>min<\/jats:sub>), systolic left ventricular development, diastolic left ventricular development, heart rate, and coronary flow at the 40, 60, 80, 100, and 120 cmH<jats:sub>2<\/jats:sub>O coronary perfusion pressure were measured in state of physiological condition (homocysteine less than 15 \u03bcmol\/L), mild HHcy, and moderate HHcy. Atorvastatin treatment significantly attenuated homocysteine-induced impairment of myocyte contractility and dominantly decreased dp\/dt<jats:sub>max<\/jats:sub>, dp\/dt<jats:sub>min<\/jats:sub>, and heart rate and induced greater changes in systolic left ventricular development compared with simvastatin. Treatment with atorvastatin seems able to revert systolic abnormalities and improve contractility during the different degrees of HHcy. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0102","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T13:48:00Z","timestamp":1533131280000},"page":"1040-1049","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficiency of atorvastatin and simvastatin in improving cardiac function during the different degrees of hyperhomocysteinemia"],"prefix":"10.1139","volume":"96","author":[{"given":"Tamara R.","family":"Nikolic Turnic","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir Lj.","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."},{"name":"Department of Human Pathology, IM Sechenov 1st Moscow State Medical University, Moscow, Russian Federation."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan M.","family":"Djuric","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, School of Medicine, University of Belgrade, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevena S.","family":"Jeremic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovana N.","family":"Jeremic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidora M.","family":"Milosavljevic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan M.","family":"Srejovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragica V.","family":"Selakovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir I.","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-017-0854-7"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7021108"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.02.018"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.2174\/157488609789006949"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2011.550570"},{"issue":"21","key":"refg7\/ref7","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1097\/00029330-200711010-00010","volume":"120","author":"Chen H.J.","year":"2007","journal-title":"Chin. 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