{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:42:46Z","timestamp":1780090966643,"version":"3.54.0"},"reference-count":34,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p> Autoimmune hepatitis (AIH) is a chronic progressive autoimmune disease characterized by hepatic inflammation. This study aimed to investigate the effect of antagomir-155 on concanavalin A (ConA)-induced AIH, and its possible mechanisms. According to the results, the expression of miR-155 was raised in liver tissues after 48 h exposure to ConA. Treatment with antagomir-155 attenuated ConA-induced liver injury in mice by reducing serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase levels. In addition, antagomir-155 significantly alleviated the differentiation of Treg\/Th17 cells in the livers of AIH mice, and suppressed Th17-cells-mediated production of pro-inflammatory cytokines IL-17A, IL-23, but not Treg-cells-mediated production of anti-inflammatory cytokine IL-10. Finally, the beneficial effect of antagomir-155 on ConA-induced AIH was abolished by administration of recombinant IL-17A. Our data demonstrated that antagomir-155 treatment could prevent AIH via regulating the differentiation of Treg and Th17 cells, suggesting that microRNA-155 may be an intriguing therapeutic target of AIH. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0467","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T21:37:56Z","timestamp":1538775476000},"page":"1293-1300","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Inhibition of microRNA-155 attenuates concanavalin-A-induced autoimmune hepatitis by regulating Treg\/Th17 cell differentiation"],"prefix":"10.1139","volume":"96","author":[{"given":"Guangtao","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sensen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143715"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-013-0509-7"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12201"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20539"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.003"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.01.002"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2290"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nature14452"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26583"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27571"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073909"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.200"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29812"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.03.003"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.035"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.08.011"},{"issue":"100","key":"refg17\/ref17","first-page":"237","volume":"18","author":"Jia S.","year":"2014","journal-title":"Discov. 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