{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:47:58Z","timestamp":1762876078188,"version":"3.41.0"},"reference-count":55,"publisher":"Canadian Science Publishing","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p> It has been assumed that the cardioprotective effects of propofol are due to its non-anesthetic pleiotropic cardiac and vasodilator effects, in which gasotransmitters (NO, H<jats:sub>2<\/jats:sub>S, and CO) as well as calcium influx could be involved. The study on isolated rat heart was performed using 4 experimental groups (n = 7 in each): (1) bolus injection of propofol (100 mg\/kg body mass, i.p.); (2) L-NAME (NO synthase inhibitor, 60 mg\/kg body mass, i.p.) + propofol; (3) DL-PAG (H<jats:sub>2<\/jats:sub>S synthase inhibitor, 50 mg\/kg body mass, i.p.) + propofol; (4) ZnPPIX (CO synthase inhibitor, 50 \u03bcmol\/kg body mass, i.p.) + propofol. Before and after the verapamil (3 \u03bcmol\/L) administration, cardiodynamic parameters were recorded (dp\/dt<jats:sub>max<\/jats:sub>, dp\/dt<jats:sub>min<\/jats:sub>, systolic left ventricular pressure, diastolic left ventricular pressure, heart rate, coronary flow), as well as coronary and cardiac oxidative stress parameters. The results showed significant increases of diastolic left ventricular pressure following NO and CO inhibition, but also increases of coronary flow following H<jats:sub>2<\/jats:sub>S and CO inhibition. Following verapamil administration, significant decreases of dp\/dt<jats:sub>max<\/jats:sub> were noted after NO and CO inhibition, then increase of diastolic left ventricular pressure following CO inhibition, and increase of coronary flow following NO, H<jats:sub>2<\/jats:sub>S, or CO inhibition. Oxidative stress markers were increased but catalase activity was significantly decreased in cardiac tissue. Gasotransmitters and calcium influx are involved in pleiotropic cardiovascular effects of propofol in male Wistar rats. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0719","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T21:36:56Z","timestamp":1558561016000},"page":"850-856","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of gasotransmitters production and calcium influx affect cardiodynamic variables and cardiac oxidative stress in propofol-anesthetized male Wistar rats"],"prefix":"10.1139","volume":"97","author":[{"given":"M.","family":"Djuric","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Clinical Hospital Center \u201cDr. Dragisa Misovic - Dedinje\u201d, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Nikolic Turnic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kostic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Radonjic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jeremic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Petkovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bradic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Milosavljevic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Srejovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Djuric","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Faculty of Medicine, University of Belgrade, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."},{"name":"Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Moscow, Russian Federation."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Clinical Hospital Center \u201cDr. Dragisa Misovic - Dedinje\u201d, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/00000542-200412000-00017","volume":"101","author":"Acquaviva R.","year":"2004","journal-title":"Anesthesiology"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12296"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200110000-00036"},{"issue":"2","key":"refg4\/ref4","first-page":"382","volume":"83","author":"Alphin R.S.","year":"1995","journal-title":"Mechanism and potential antidysrhythmic properties. 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