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The aim of this study was to test the potential antioxidant and anti-inflammatory effects of febuxostat and (or) stopping a high-fat diet on the biochemical parameters in rabbits with hyperlipidemia induced by a high-fat diet. Male New Zealand rabbits were distributed into 3 groups: a normal control group fed standard chow for 12 weeks and 2 other groups fed a high-fat diet with 1% cholesterol for 8 weeks, and then shifted to standard chow for 4 weeks. During the last 4 weeks, one high-fat diet group received 0.5% carboxymethyl cellulose, whereas the other group was treated with febuxostat (2 mg\/kg per day p.o.). Febuxostat significantly lowered low-density lipoprotein cholesterol (\u201cbad\u201d cholesterol) compared to the untreated group (high-fat diet group). Febuxostat also displayed a potent anti-inflammatory and antioxidant activity by decreasing serum levels of lipid peroxidation index, proinflammatory cytokines, and enhancing antioxidant enzyme activity. Stopping the hyperlipidemic diet in the high-fat diet group did not show improvement. These findings indicate the antioxidant and anti-inflammatory effects of febuxostat that may be common mechanisms of the anti-hyperlipidemic effect of this drug. Stopping a hyperlipidemic diet without treatment is not sufficient once injury has occurred. <\/jats:p>","DOI":"10.1139\/cjpp-2018-0731","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T21:36:17Z","timestamp":1551476177000},"page":"611-622","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of febuxostat on biochemical parameters of hyperlipidemia induced by a high-fat diet in rabbits"],"prefix":"10.1139","volume":"97","author":[{"given":"Mohammed M.","family":"Heikal","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Shaaban","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt."},{"name":"Faculty of Pharmacy, Aqaba University of Technology, Jordan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagdi F.","family":"Elkashef","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/clinchem\/20.4.470","volume":"20","author":"Allain C.C.","year":"1974","journal-title":"Clin. 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