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Compared to normal control and normal pregnant control mice, GDM mice before and after delivery showed significantly cardiac injury. RA treatment attenuated cardiac injury as evidenced by decreased heart mass and left ventricular mass, mRNA expressions of ANP and BNP, and cardiac fibrosis compared with that in GDM mice. The protective effect of RA on GDM cardiomyopathy was related to the decreased MDA content and ROS generation, the increased GSH-Px and SOD content as well as the reduced TNF-\u03b1 and IL-1\u03b2 content and inhibition of NF-\u03baB signaling. In addition, RA treatment delayed the continuous rise of blood glucose before delivery and decreased the higher level of glucose after delivery. In conclusion, RA treatment could increase the activity of the antioxidant enzyme and suppress the oxidative stress, inflammation response, and activation of NF-\u03baB signaling, thereby improving blood glucose level and cardiac injury of GDM mice before and after delivery. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0009","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T21:42:35Z","timestamp":1568410955000},"page":"6-14","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Retinoic acid attenuates cardiac injury induced by hyperglycemia in pre- and post-delivery mice"],"prefix":"10.1139","volume":"98","author":[{"given":"Yun","family":"Liu","sequence":"first","affiliation":[{"name":"Shenyang Hehe Medical Test Institute, Shenyang, Liaoning Province 100200, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Jinzhou Maternal and Infant Hospital, Jinzhou, Liaoning Province 121001, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meili","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, Liaoning Province 121001, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, Liaoning Province 121001, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Futian","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730000, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1487525"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1759"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1310193"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60731-5"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.10.006"},{"key":"refg6\/ref6","unstructured":"CEMACH. 2002. 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