{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:14:21Z","timestamp":1781734461973,"version":"3.54.5"},"reference-count":41,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p> Stanniocalcin-1 and -2 belong to a family of molecules that exhibit both paracrine and autocrine effects in mammalian cells. Human stanniocalcin-1 (hSTC-1) is expressed in a wide range of tissues, including white adipose tissue. In fed rats, hSTC-1 increases carbon flux from glucose to lipids in retroperitoneal white adipose tissue. Human stanniocalcin-2 (hSTC-2) is expressed in almost all tissues and regulates various biological processes. The aim of this work was to study the action of hSTC-1 and hSTC-2 in the lipid and glucose metabolism of epididymal white adipose tissue (eWAT) in rats in different nutritional states. This study shows for the first time an opposite effect of hSTC-1 and hSTC-2 on glyceride-glycerol generation from glucose in eWAT of fed rats. hSTC-1 stimulated the storage of triacylglycerol in eWAT in the postprandial period, increasing glucose uptake and glyceride-glycerol generation from <jats:sup>14<\/jats:sup>C-glucose. hSTC-2 decreased triacylglycerol synthesis, reducing glyceride-glycerol generation from <jats:sup>14<\/jats:sup>C-glucose, direct phosphorylation of glycerol, and fatty acid synthesis from <jats:sup>14<\/jats:sup>C-glucose in eWAT of fed rats. However, both hormones increased glucose uptake in fed and fasting states. These findings provide evidence for a direct role of hSTC-1 and hSTC-2 in the regulation of lipid and glucose metabolism in eWAT of rats. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0023","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T21:42:21Z","timestamp":1558129341000},"page":"916-923","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Stanniocalcin-1 and -2 effects on glucose and lipid metabolism in white adipose tissue from fed and fasted rats"],"prefix":"10.1139","volume":"97","author":[{"given":"Elaine","family":"Sarapio","sequence":"first","affiliation":[{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."},{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir K.","family":"De Souza","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."},{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge F.A.","family":"Model","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."},{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Trapp","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."},{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselis S.M.","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."},{"name":"Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.10.007"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979967"},{"key":"refg3\/ref3","first-page":"631","volume":"22","author":"Bueno D.","year":"1994","journal-title":"Med. 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