{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:09:43Z","timestamp":1758892183755,"version":"3.41.0"},"reference-count":44,"publisher":"Canadian Science Publishing","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p> This study aimed to investigate the effects of propofol through evaluating its interaction with nitric oxide (NO), hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), and carbon monoxide (CO). Wistar male rats were divided in 4 groups: (1) bolus injection of propofol (1% 10 mg\/mL, 100 mg\/kg bw, i.p.); (2) N<jats:sup>\u03c9<\/jats:sup>-nitro-l-arginine methyl ester (L-NAME; NO synthase inhibitor, 60 mg\/kg bw, i.p.) + bolus injection of propofol (1% 10 mg\/mL, 100 mg\/kg bw, i.p.); (3) DL-propargylglycine (DL-PAG; H<jats:sub>2<\/jats:sub>S synthase inhibitor, 50 mg\/kg bw, i.p.) + bolus injection of propofol (1% 10 mg\/mL, 100 mg\/kg bw, i.p.); (4) zinc protoporphyrin IX (ZnPPIX; CO synthase inhibitor, 50 \u03bcmol\/kg bw, i.p.) + bolus injection of propofol (1% 10 mg\/mL, 100 mg\/kg bw, i.p.). Increased levels of albumins, low-density lipoproteins, alkaline phosphatase, amylase, high-sensitivity Troponin T, and fibrinogen were found in L-NAME + propofol group. Platelet crit, platelet count, total cholesterol, and high-density lipoproteins were elevated in ZnPPIX + propofol group. Hydrogen peroxide was increased in all groups treated with gasotransmitters inhibitors. Reduced glutathione was reduced in all groups, superoxide dismutase activity only in L-NAME + propofol. The effect of propofol on various biochemical, haematological, and oxidative stress markers may be at least in part mediated through interaction with 3 estimated gasotransmitters. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0029","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T18:55:47Z","timestamp":1568919347000},"page":"1073-1079","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The effects of gasotransmitters inhibition on biochemical and haematological parameters and oxidative stress in propofol-anaesthetized Wistar male rats"],"prefix":"10.1139","volume":"97","author":[{"given":"M.","family":"Djuric","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Clinical Hospital Center \u201cDr. Dragisa Misovic - Dedinje\u201d, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Nikolic Turnic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kostic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Centre of Medical Biochemistry, Clinical Centre of Serbia, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Radonjic","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Djuric","sequence":"additional","affiliation":[{"name":"Institute of Medical Physiology \u201cRichard Burian\u201d, Faculty of Medicine, University of Belgrade, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia."},{"name":"Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Moscow, Russian Federation."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Clinical Hospital Center \u201cDr. Dragisa Misovic - Dedinje\u201d, Belgrade, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/230261"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12296"},{"issue":"4","key":"refg3\/ref3","first-page":"454","volume":"49","author":"Alves H.N.","year":"2010","journal-title":"J. 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