{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:18:04Z","timestamp":1751516284691,"version":"3.41.0"},"reference-count":26,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p> The coexistence of different visceral pathologies in patients suffering from irritable bowel syndrome, interstitial cystitis, and other pathologies, necessitates the study of these pathologies under complicated conditions. In the present study, cystometry recordings were used to investigate the effect of distal esophageal chemical irritation on the urinary bladder interaction with distal colon distention, distal esophageal distention, and electrical stimulation of abdominal branches of vagus nerve. Distal esophageal chemical irritation significantly decreased the intercontraction time via decreasing the voiding time. Also, distal esophageal chemical irritation significantly decreased the pressure amplitude by decreasing the maximum pressure. Following distal esophageal chemical irritation, distal esophageal distention was able to significantly decrease the intercontraction time by decreasing the storage time. However, 3 mL distal colon distention significantly increased the intercontraction time by increasing the storage time. On the other hand, following distal esophageal chemical irritation, electrical stimulation of abdominal branches of vagus nerve did not have any significant effect on intercontraction time. However, electrical stimulation of abdominal branches of vagus nerve significantly increased the pressure amplitude by increasing the maximum pressure. The results of this study demonstrate that urinary bladder function and interaction of bladder with other viscera can be affected by chemical irritation of distal esophagus. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0122","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T21:37:11Z","timestamp":1556055431000},"page":"766-772","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats"],"prefix":"10.1139","volume":"97","author":[{"given":"Ezidin G.","family":"Kaddumi","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan."},{"name":"Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt, Jordan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.2.545"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20789"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.69.3.868"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(92)90245-7"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000128428.74337.ef"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01606.x"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0326-6"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-5538.IBJU.2015.0238"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.102574"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21173"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22270"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-08-03043.1998"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91758-9"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.09.051"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12307"},{"key":"refg16\/ref16","doi-asserted-by":"crossref","unstructured":"Meyer, R.E., and Fish, R.E. 2008. 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