{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:16:10Z","timestamp":1762604170227,"version":"3.41.0"},"reference-count":34,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p> Smoking is associated with endothelial and left ventricular diastolic disfunction. We aimed to determine the endothelial and diastolic function in young adults exposed to tobacco smoke and the effects of acute exposure to it. Smokers were considered as cases and non-smokers as controls. Brachial artery diameter, brachial artery flow velocity, and echocardiographic variables were measured. Mean age of the participants was 21 years. Smokers showed significant endothelial dysfunction compared with non-smokers. Arterial dilation mediated by the endothelium was significantly higher in non-smokers than in smokers (p = 0.005). Non-endothelium-mediated arterial dilation was significantly impaired in smokers compared with non-smokers (p = 0.02). After reactive hyperaemia, there was a significant increase in blood flow in non-smokers (61%) compared with that in smokers (29%). Acute cigarette exposure showed a trend towards left ventricle diastolic disfunction in smokers. Left atrium diameter was significantly higher in smokers than in non-smokers. After acute exposure to cigarette smoke, arterial dilation and brachial flow velocity were lower than those achieved in the abstinence phase (p = 0.005). We concluded that endothelium-dependent arterial dilation is impaired in young smokers and it worsens even after acute exposure to cigarette smoke. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0187","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T21:35:49Z","timestamp":1562189749000},"page":"1006-1011","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Endothelial and left ventricular diastolic function in young adults exposed to tobacco"],"prefix":"10.1139","volume":"97","author":[{"given":"Ayelen","family":"Rodriguez-Portelles","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delfin","family":"Rodriguez-Leyva","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada."},{"name":"Department of Physiology and Pathophysiology, Department of Internal Medicine, Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0W2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsha.2013.03.003"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.02.037"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.827566"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601183340303"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652859"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.023"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.11.009"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1136\/tc.2004.009621"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.1.6"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.5717\/jenb.2014.18.3.239"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.002"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060250"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i5.601"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(99)00203-X"},{"issue":"1","key":"refg19\/ref19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0022-3565(24)37807-3","volume":"287","author":"Macklin K.D.","year":"1998","journal-title":"J. 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