{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:16:34Z","timestamp":1780384594126,"version":"3.54.1"},"reference-count":137,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p> Homocysteine (Hcy), a sulfur-containing nonproteinogenic amino acid, is generated as a metabolic intermediate. Hcy constitutes an important part of the \u201c1-carbon metabolism\u201d during methionine turnover. Elevated levels of Hcy known as hyperhomocysteinemia (HHcy) results from vitamin B deficiency, lack of exercise, smoking, excessive alcohol intake, high-fat and methionine-rich diet, and the underlying genetic defects. These factors directly affect the \u201c1-carbon metabolism (methionine\u2013Hcy\u2013folate)\u201d of a given cell. In fact, the Hcy levels are determined primarily by dietary intake, vitamin status, and the genetic blueprint of the susceptible individual. Although Hcy performs an important role in cellular functions, genetic alterations in any of the key enzymes responsible for the \u201c1-carbon metabolism\u201d could potentially upset the metabolic cycle, thus causing HHcy environment in susceptible people. As such, HHcy relates to several clinical conditions like atherosclerosis, myocardial infarction, stroke, cognitive impairment, dementia, Parkinson\u2019s disease, multiple sclerosis, epilepsy, and ocular disorders, among others. This article summarizes the findings from our laboratory and public database regarding genetics of HHcy and its effects on ocular disorders, their respective management during dysregulation of the 1-carbon metabolism. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0236","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T21:36:42Z","timestamp":1564695402000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Genes and genetics in hyperhomocysteinemia and the \u201c1-carbon metabolism\u201d: implications for retinal structure and eye functions"],"prefix":"10.1139","volume":"98","author":[{"given":"Akash K.","family":"George","sequence":"first","affiliation":[{"name":"Eye and Vision Science Laboratory, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."},{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avisek","family":"Majumder","sequence":"additional","affiliation":[{"name":"Department of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Ice","sequence":"additional","affiliation":[{"name":"Eye and Vision Science Laboratory, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."},{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens P.","family":"Homme","sequence":"additional","affiliation":[{"name":"Eye and Vision Science Laboratory, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."},{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wintana","family":"Eyob","sequence":"additional","affiliation":[{"name":"College of Arts and Sciences, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh C.","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahavir","family":"Singh","sequence":"additional","affiliation":[{"name":"Eye and Vision Science Laboratory, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."},{"name":"Department of Physiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","unstructured":"Ajith, T.A., and Ranimenon. 2015. Homocysteine in ocular diseases. Clin. Chim. Acta, 450: 316\u2013321. 10.1016\/j.cca.2015.09.007. 26343924.","DOI":"10.1016\/j.cca.2015.09.007"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.02.017"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-006-0098-x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.06.009"},{"key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s007020200097","volume":"109","author":"Bleich S.","year":"2002","journal-title":"J. Neural Transm. (Vienna)"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0632"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009007500021"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.3892\/br.2014.357"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0706-5"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg039"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0106-5"},{"key":"refg12\/ref12","first-page":"1946","volume":"17","author":"Chang H.H.","year":"2011","journal-title":"Mol. Vis."},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.810542"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500000751"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701853"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2667"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614070"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.08.029"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0112"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-7-199910050-00033"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-194-43110"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-401513"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00788-8"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1080\/13816810600677883"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(90)90070-2"},{"key":"refg26\/ref26","first-page":"9508","volume":"259","author":"Finkelstein J.D.","year":"1984","journal-title":"Distribution of homocysteine between competing pathways. J. Biol. Chem."},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(75)80297-X"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399410001651"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.09.007"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00465.2004"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3402"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.3109\/02713680903421194"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.07.038"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23568-z"},{"key":"refg36\/ref36","first-page":"881","volume":"11","author":"George A.K.","year":"2018","journal-title":"Int. J. Ophthalmol."},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.057091"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2009.10.019"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199802270-00016"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.07.028"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501452200"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.956839"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11058-9"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu152"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10416"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2017.01522"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2011.578778"},{"key":"refg48\/ref48","doi-asserted-by":"crossref","first-page":"8532","DOI":"10.18632\/oncotarget.7384","volume":"7","author":"Ibrahim A.S.","year":"2016","journal-title":"Oncotarget"},{"key":"refg49\/ref49","first-page":"308","volume":"19","author":"Iqbal M.P.","year":"2009","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"refg50\/ref50","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.1.7"},{"key":"refg137\/ref137","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.97802"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.377S"},{"key":"refg52\/ref52","first-page":"30425","volume":"277","author":"Jakubowski H.","year":"2002","journal-title":"Implications for homocysteine-linked disease. J. Biol. Chem."},{"key":"refg53\/ref53","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1741S"},{"key":"refg54\/ref54","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/ars.2005.7.813","volume":"7","author":"Jhee K.H.","year":"2005","journal-title":"Antioxid. Redox Signal"},{"key":"refg55\/ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.09.081"},{"key":"refg56\/ref56","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13234"},{"key":"refg57\/ref57","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70102-2"},{"key":"refg58\/ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2013.07.002"},{"key":"refg59\/ref59","doi-asserted-by":"crossref","first-page":"623","DOI":"10.33549\/physiolres.931566","volume":"58","author":"Karolczak K.","year":"2009","journal-title":"Physiol. Res."},{"key":"refg60\/ref60","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9204-9"},{"key":"refg61\/ref61","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.156695"},{"key":"refg62\/ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.02.009"},{"key":"refg63\/ref63","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.10.1633"},{"key":"refg64\/ref64","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-18-06920.2000"},{"key":"refg65\/ref65","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105278"},{"key":"refg66\/ref66","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60657"},{"key":"refg67\/ref67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.11.5923"},{"key":"refg68\/ref68","doi-asserted-by":"publisher","unstructured":"Loscalzo, J., and Handy, D.E. 2014. Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series). Pulm. Circ. 4: 169\u2013174. 10.1086\/675979. 25006435.","DOI":"10.1086\/675979"},{"key":"refg69\/ref69","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25841"},{"key":"refg70\/ref70","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00147.2018"},{"key":"refg71\/ref71","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13858"},{"key":"refg72\/ref72","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27603"},{"key":"refg73\/ref73","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/clinchem\/40.6.857","volume":"40","author":"Malinow M.R.","year":"1994","journal-title":"Clin. Chem."},{"key":"refg74\/ref74","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.1.178"},{"key":"refg75\/ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2003.12.019"},{"key":"refg76\/ref76","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-011-9444-x"},{"key":"refg77\/ref77","first-page":"111","volume":"56","author":"McCully K.S.","year":"1969","journal-title":"Am. J. Pathol."},{"key":"refg78\/ref78","first-page":"477","volume":"23","author":"McCully K.","year":"1993","journal-title":"Ann. Clin. Lab. Sci."},{"key":"refg79\/ref79","first-page":"219","volume":"39","author":"McCully K.S.","year":"2009","journal-title":"Ann. Clin. Lab. Sci."},{"key":"refg80\/ref80","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/j.2040-4603.2016.tb00682.x","volume":"6","author":"McCully K.S.","year":"2015","journal-title":"Compr. Physiol."},{"key":"refg81\/ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.02.033"},{"key":"refg82\/ref82","first-page":"661","volume":"14","author":"Michael S.","year":"2008","journal-title":"Mol. Vis."},{"key":"refg83\/ref83","first-page":"2268","volume":"15","author":"Micheal S.","year":"2009","journal-title":"Mol. Vis."},{"key":"refg84\/ref84","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.151753"},{"key":"refg85\/ref85","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09731-y"},{"key":"refg86\/ref86","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.1009"},{"key":"refg87\/ref87","first-page":"356","volume":"12","author":"Mossbock G.","year":"2006","journal-title":"Mol. Vis."},{"key":"refg88\/ref88","first-page":"4382","volume":"240","author":"Mudd S.H.","year":"1965","journal-title":"Microassays and tissue distributions of three enzymes of the pathway. J. Biol. Chem."},{"key":"refg89\/ref89","doi-asserted-by":"publisher","DOI":"10.1067\/mpa.2001.118219"},{"key":"refg90\/ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2004.01.010"},{"key":"refg91\/ref91","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0905"},{"key":"refg92\/ref92","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005554702861"},{"key":"refg93\/ref93","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000201039.21705.dc"},{"key":"refg94\/ref94","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.06.015"},{"key":"refg95\/ref95","doi-asserted-by":"publisher","DOI":"10.1159\/000065076"},{"key":"refg96\/ref96","doi-asserted-by":"publisher","DOI":"10.1016\/0885-4505(92)90029-X"},{"key":"refg97\/ref97","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.19.1.217"},{"key":"refg98\/ref98","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1726S"},{"key":"refg99\/ref99","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-5-199909070-00003"},{"key":"refg100\/ref100","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.6.635"},{"key":"refg101\/ref101","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.05.026"},{"key":"refg102\/ref102","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2296-8"},{"key":"refg103\/ref103","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.34017"},{"key":"refg104\/ref104","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1515\/CCLM.2005.179","volume":"43","author":"Stanger O.","year":"2005","journal-title":"Clin. Chem. Lab. Med."},{"key":"refg105\/ref105","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-009-9006-9"},{"key":"refg106\/ref106","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.3.467"},{"key":"refg107\/ref107","doi-asserted-by":"publisher","unstructured":"Sunder-Plassmann, G., and Fodinger, M. 2003. Genetic determinants of the homocysteine level. Kidney Int. Suppl. S141\u2013S144. 10.1046\/j.1523-1755.63.s84.52.x. 12694331.","DOI":"10.1046\/j.1523-1755.63.s84.52.x"},{"key":"refg108\/ref108","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10536"},{"key":"refg109\/ref109","first-page":"1023","volume":"1","author":"Tawfik A.","year":"2014","journal-title":"Austin J. Clin. Ophthalmol."},{"key":"refg110\/ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.05.018"},{"key":"refg111\/ref111","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.151555"},{"key":"refg112\/ref112","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.14.6369"},{"key":"refg113\/ref113","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/CIA.S9918","volume":"5","author":"Turgut B.","year":"2010","journal-title":"Clin. Interv. Aging"},{"key":"refg114\/ref114","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00548.2005"},{"key":"refg115\/ref115","first-page":"441","volume":"46","author":"Tyagi N.","year":"2009","journal-title":"Indian J. Biochem. Biophys."},{"key":"refg116\/ref116","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.274.2.C396"},{"key":"refg117\/ref117","doi-asserted-by":"publisher","DOI":"10.3109\/10641969909068660"},{"key":"refg118\/ref118","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-05-0313"},{"key":"refg119\/ref119","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140715074"},{"key":"refg120\/ref120","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.3.553"},{"key":"refg121\/ref121","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-013-2387-3"},{"key":"refg122\/ref122","first-page":"1690","volume":"81","author":"Watkins D.","year":"1988","journal-title":"Definition of two complementation groups, cblE and cblG. J. Clin. Invest."},{"key":"refg123\/ref123","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340320"},{"key":"refg124\/ref124","doi-asserted-by":"publisher","DOI":"10.2174\/1389200052997357"},{"key":"refg125\/ref125","doi-asserted-by":"crossref","first-page":"I4","DOI":"10.1161\/01.CIR.0000078468.11849.66","volume":"107","author":"White R.H.","year":"2003","journal-title":"Circulation"},{"key":"refg126\/ref126","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702920"},{"key":"refg127\/ref127","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2721-3"},{"key":"refg128\/ref128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.09.006"},{"key":"refg129\/ref129","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033222"},{"key":"refg130\/ref130","doi-asserted-by":"publisher","DOI":"10.3892\/br.2014.302"},{"key":"refg131\/ref131","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.10.004"},{"key":"refg132\/ref132","first-page":"2060","volume":"91","author":"Yu H.H.","year":"2011","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"refg133\/ref133","doi-asserted-by":"publisher","DOI":"10.1021\/ac9017132"},{"key":"refg134\/ref134","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ14-0071"},{"key":"refg135\/ref135","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.4.F671"},{"key":"refg136\/ref136","doi-asserted-by":"crossref","first-page":"318471","DOI":"10.1155\/2013\/318471","volume":"2013","author":"Zivkovic V.","year":"2013","journal-title":"Biomed. Res. Int."}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2019-0236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2019-0236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T17:30:50Z","timestamp":1751477450000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2019-0236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":137,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1139\/cjpp-2019-0236"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2019-0236","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}