{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:08:30Z","timestamp":1772136510517,"version":"3.50.1"},"reference-count":36,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p> Xerostomia is a self-conscious symptom. High-mobility group box 1 (HMGB1) promotes pro-inflammatory effects in many diseases. This study aimed to clarify the role of HMGB1 in Sj\u00f6gren syndrome (SS)-triggered xerostomia. Nonobese diabetic (NOD)\/Ltj mice were used to establish an SS-triggered xerostomia model. The results showed that saliva production was decreased and anti-Sj\u00f6gren syndrome B (anti-SSB) level was increased in SS. PCR, Western blot, and immunohistochemistry experiments indicated that the HMGB1 and aquaporin 5 (AQP5) levels were enhanced and diminished in SS compared with those in the control, respectively. While the mice were treated with anti-HMGB1, xerostomia was reversed due to the elevated saliva production and reduced anti-SSB level. In addition, it was found that the inhibition of HMGB1 restrained the toll-like receptor 4 (TLR4)\/nuclear factor kappa B (NF-\u03baB) axis activation. The TLR4 and p-I\u03baB levels were alleviated, while the I\u03baB\u03b1 and NF-\u03baB p65 levels were augmented. The NF-\u03baB p65 binding activity was attenuated via the electrophoretic mobility shift assay (EMSA) after anti-HMGB1 treatment. Moreover, the repression of HMGB1 facilitated the expression of AQP5. These findings demonstrate that suppression of HMGB1 ameliorates SS-triggered xerostomia via suppressing the HMGB1\/TLR4\/NF-\u03baB signaling pathway and upregulating AQP5 expression. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0337","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T21:35:18Z","timestamp":1579037718000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Suppression of high-mobility group box 1 ameliorates xerostomia in a Sj\u00f6gren syndrome-triggered mouse model"],"prefix":"10.1139","volume":"98","author":[{"given":"Di","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."},{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."},{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."},{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiren","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."},{"name":"Department of Nephrology, Xijing Hospital, The First Affiliated Hospital of Fourth Military Medical University, Xi\u2019an, Shaanxi 710032, People\u2019s Republic of China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3332"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1080\/000163501750266684"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206860"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000088179"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2011.633099"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1002\/art.21969"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-013-0243-0"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.336255"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.1.G247"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13025"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.222"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316644331"},{"issue":"5","key":"refg13\/ref13","first-page":"1019","volume":"34","author":"Kawakami A.","year":"2007","journal-title":"J. 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