{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:59:16Z","timestamp":1778741956676,"version":"3.51.4"},"reference-count":34,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p> Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl<jats:sub>4<\/jats:sub>-induced acute liver injury, especially its effect on the Nrf2\/HO-1 signaling pathway. For the in vivo experiment, an acute liver injury model was induced using CCl<jats:sub>4<\/jats:sub> and treated with Sal B. For the in vitro experiment, an oxidative damage model was established followed by Sal B treatment. Serum biochemical indicators and reactive oxygen species activity were detected using corresponding kits. Oxidant\/antioxidant status was determined based on the levels of malondialdehyde, glutathione, and superoxide dismutase. Nrf2 and HO-1 levels were analyzed by Western blotting and immunohistochemical staining. Sal B treatment improved liver histology, decreased the aminotransferase levels, and attenuated oxidative stress in the acute liver injury model. Nrf2 and HO-1 levels were increased both in vivo and in vitro. Sal B suppresses acute liver injury and Nrf2\/HO-1 signaling plays a key role in this process. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0349","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T21:36:36Z","timestamp":1570829796000},"page":"162-168","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Salvianolic acid B exerts a protective effect in acute liver injury by regulating the Nrf2\/HO-1 signaling pathway"],"prefix":"10.1139","volume":"98","author":[{"given":"Yong-mei","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui 230022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-ming","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei, Anhui 230032, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-ning","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui 230022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youjin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui 230022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-yu","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Anhui Medical University, Hefei, Anhui 230022, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-220"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(99)00085-6"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-012-1052-8"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01487"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.07.030"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07486.x"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(89)90016-1"},{"key":"refg8\/ref8","unstructured":"Das, D.K. 2010. 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