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Here, we evaluated whether the pharmacokinetics of mycophenolic acid (MPA), an immunosuppressant, would be altered in rats with NAFLD. NAFLD was induced by feeding a diet containing 1% (w\/w) orotic acid for 20 days. The extent of hepatic glucuronidation of MPA to a major metabolite, mycophenolic acid-7-O-glucuronide (MPAG), did not differ between rats with NAFLD and controls. The expression levels of hepatic multidrug resistance-associated protein 2, responsible for biliary excretion of MPAG, were comparable in rats with NAFLD and controls; the biliary excretion of MPAG was also similar in the two groups. Compared with control rats, rats with NAFLD did not exhibit significant changes in the areas under the plasma concentration\u2009\u2013\u2009time curves of MPA or MPAG after intravenous (5 mg\/kg) or oral (10 mg\/kg) administration of MPA. However, delayed oral absorption of MPA was observed in rats with NAFLD compared with controls; the MPA and MPAG peak plasma concentrations fell significantly and the times to achieve them were prolonged following oral administration of MPA. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0383","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T21:48:53Z","timestamp":1572040133000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The pharmacokinetics of mycophenolic acid in rats with orotic acid induced nonalcoholic fatty liver disease"],"prefix":"10.1139","volume":"98","author":[{"given":"Dionysius","family":"Subali","sequence":"first","affiliation":[{"name":"Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia."},{"name":"College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, Catholic University of Korea, Bucheon 14662, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Hye","family":"Kwon","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, Catholic University of Korea, Bucheon 14662, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Seok","family":"Bang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, Catholic University of Korea, Bucheon 14662, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Eun","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, Catholic University of Korea, Bucheon 14662, South Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000189898.23931.3f"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.18433\/jpps30268"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01487.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199834060-00002"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.046177"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.055996"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.062703"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.62.508"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1007\/BF01062108"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(95)49031-0"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.220764"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.66"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.027466"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.04.002"},{"key":"refg15\/ref15","doi-asserted-by":"crossref","unstructured":"Gibaldi M, Perrier, D. 1982. 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