{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:39:27Z","timestamp":1776875967230,"version":"3.51.2"},"reference-count":54,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p> Pregnane X receptors (PXRs) regulate the expression of ATP-binding cassette proteins transporters and organic anion transporting polypeptides responsible for influx\/efflux of xenobiotics across the brain. Ligand activation of PXR augments the expression of P-gp and promotes amyloid-\u03b2 clearance across the blood\u2013brain barrier. Dementia was induced in mice by intacerebroventricular administration of streptozotocin (STZ) followed by treatment with meclizine, a PXR agonist, and subsequently exposed to the Morris water maze test and biochemical and histopathological analysis to evaluate the effect on cognition. STZ-treated mice exhibited significant enhancement in brain thiobarbituric acid reactive species, interleukin-1\u03b2, tumour necrosis factor-\u03b1, myeloperoxidase, and acetylcholinestrase activity in addition to diminution in glutathione levels and superoxide dismutase activity in comparison to untreated mice. Administration of meclizine to STZ mice recuperated cognition and biochemical alterations. Concomitant administration of ketoconazole, a PXR antagonist, with meclizine prevented the protective effects. The upshots of our study proclaim that meclizine protects cognitive deficits by virtue of its antioxidant, anticholinesterase, and antiinflammatory properties. Results also signify the potential of PXR in neuroprotective actions of meclizine in dementia. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0421","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T21:38:08Z","timestamp":1579037888000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Meclizine ameliorates memory deficits in streptozotocin-induced experimental dementia in mice: role of nuclear pregnane X receptors"],"prefix":"10.1139","volume":"98","author":[{"given":"Harmandeep","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."},{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupinder Kaur","family":"Sodhi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."},{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simerjeet Kaur","family":"Chahal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."},{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitender","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."},{"name":"Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab), India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.18433\/J36016"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.129650"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20461"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1124\/mol.66.3"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.023796"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.10.038"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8375-5"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.3109\/10520290903389445"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2019.04.010"},{"key":"refg57\/ref57","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.038398"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.03.005"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1002\/gps.934"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00106"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12173"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12116"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010173200"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201515"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1606"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq464"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04368.x"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2011.567391"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1038\/srep25344"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200082"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0046"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.03.009"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2014.06.012"},{"key":"refg63\/ref63","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318190b691"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20562"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.07.035"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001-0038"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007583"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90202-6"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.43.277"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00075.x"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2013.01.005"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.112.5.1199"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.175927"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9102"},{"key":"refg48\/ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.061"},{"key":"refg49\/ref49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry O.H.","year":"1951","journal-title":"J. Biol. Chem."},{"key":"refg50\/ref50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JAD-2012-120958","volume":"33","author":"Mehla J.","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/925702"},{"key":"refg51\/ref51","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"refg52\/ref52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1968.tb00428.x"},{"key":"refg53\/ref53","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.149690"},{"key":"refg54\/ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.01.057"},{"key":"refg55\/ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.08.008"},{"key":"refg56\/ref56","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1184"},{"key":"refg58\/ref58","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00611-6"},{"key":"refg59\/ref59","doi-asserted-by":"publisher","DOI":"10.1177\/1470320312459977"},{"key":"refg60\/ref60","doi-asserted-by":"publisher","DOI":"10.2174\/138920006776873535"},{"key":"refg61\/ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.09.012"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2019-0421","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2019-0421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:57:46Z","timestamp":1751471866000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2019-0421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":54,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1139\/cjpp-2019-0421"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2019-0421","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"2019-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}