{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:03:19Z","timestamp":1790510599614,"version":"4.1.0"},"reference-count":56,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p> Apelin is a peptide that plays a role in physiological processes such as angiogenesis, apoptosis, and proliferation. The aim of this study was to investigate the role of capsaicin-sensitive afferent neurons and vagus in the effect of apelin against ischemia\/reperfusion (I\/R) injury. The experimental groups were (1) control, (2) I\/R, (3) apelin + I\/R, (4) vagotomy + I\/R, (5) vagotomy + apelin + I\/R, (6) capsaicin + I\/R, (7) capsaicin + apelin + I\/R, (8) lorglumide + I\/R, and (9) lorglumide + apelin + I\/R. To test the potential gastroprotective effect of apelin-13, apelin-13 (2 mg\/kg i.v.) was administered just before both ischemia and reperfusion. A vagotomy was performed 1 week before I\/R in the vagotomized groups; capsaicin (125 mg\/kg s.c.) was administrated 2 weeks before I\/R in the capsaicin-treated groups and lorglumide (5 mg\/kg i.p.) was administered 30 min before I\/R in the lorglumide-treated groups. After I\/R, a variety parameters in gastric tissue were analyzed. cfos expression was determined in brainstem samples. In the I\/R group, the lesion index, myeloperoxidase activity, lipid peroxidation, nitric oxide, and tumor necrosis factor-\u03b1 increased, and mucosal blood flow, prostaglandin-E<jats:sub>2<\/jats:sub>, and calcitonin gene related peptide decreased. Apelin prevented the damaging effects of I\/R and increased cfos expression in brainstem areas. Vagotomy, capsaicin, and lorglumide largely eliminated the gastroprotective effects of apelin-13. This study showed that sensory nerves and the vagus play regulatory roles in apelin-induced gastroprotection. Cholecystokinin may play a role in the effect of apelin through sensory neurons. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0502","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T19:10:21Z","timestamp":1576005021000},"page":"282-295","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of apelin-13 on gastric ischemia\/reperfusion injury: the roles of sensory nerves and vagus nerve"],"prefix":"10.1139","volume":"98","author":[{"given":"\u0130lknur","family":"Birsen","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Biruni University, 34096 \u0130stanbul, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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