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At initial stages, cardiac hypertrophy is associated with normal or enhanced cardiac function and is considered to be adaptive or physiological; however, at later stages, if the stimulus is not removed, it is associated with contractile dysfunction and is termed as pathological cardiac hypertrophy. It is during physiological cardiac hypertrophy where the function of subcellular organelles, including the sarcolemma, sarcoplasmic reticulum, mitochondria, and myofibrils, may be upregulated, while pathological cardiac hypertrophy is associated with downregulation of these subcellular activities. The transition of physiological cardiac hypertrophy to pathological cardiac hypertrophy may be due to the reduction in blood supply to hypertrophied myocardium as a consequence of reduced capillary density. Oxidative stress, inflammatory processes, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -handling abnormalities, and apoptosis in cardiomyocytes are suggested to play a critical role in the depression of contractile function during the development of pathological hypertrophy.\n                  <\/jats:p>","DOI":"10.1139\/cjpp-2019-0566","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T16:35:34Z","timestamp":1575909334000},"page":"74-84","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":197,"title":["Mechanisms for the transition from physiological to pathological cardiac hypertrophy"],"prefix":"10.1139","volume":"98","author":[{"given":"Christopher J.","family":"Oldfield","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology & Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada."},{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Duhamel","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology & Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada."},{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naranjan S.","family":"Dhalla","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada."},{"name":"Department of Physiology & Pathophysiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.260.5.H1552"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.52.1.57"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0149"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.72.2.463"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01309"},{"key":"refg6\/ref6","first-page":"157","volume":"15","author":"Arsenescu G.","year":"1978","journal-title":"Physiologie"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22404"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-018-9716-x"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.151"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00378.2004"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.5.480"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164680"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.005"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.75.1.23"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11514"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711063371906"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00493-X"},{"key":"refg18\/ref18","first-page":"298","volume":"15","author":"Cannon J.G.","year":"2000","journal-title":"News Physiol. 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