{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:48:46Z","timestamp":1787863726230,"version":"build-2784847793"},"reference-count":42,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p> Diabetes mellitus is a metabolic disorder that can generate tissue damage through several pathways. Alteration and dysfunction of skeletal muscle are reported including respiratory muscles, which may compromise respiratory parameters in diabetic patients. We have aimed to evaluate the diaphragm muscle contractility, tissue remodeling, oxidative stress, and inflammatory parameters from 30 day streptozotocin-treated rats. The diaphragm contractility was assessed using isolated muscle, tissue remodeling using histology and zymography techniques, and tissue oxidative stress and inflammatory parameters by enzyme activity assay. Our data revealed in the diabetes mellitus group an increase in maximum tetanic force (4.82 \u00b1 0.13 versus 4.24 \u00b1 0.18 N\/cm<jats:sup>2<\/jats:sup> (p = 0.015)) and fatigue resistance (139.16 \u00b1 10.78 versus 62.25 \u00b1 4.45 s (p &lt; 0.001)), reduction of 35.4% in muscle trophism (p &lt; 0.001), increase of 32.6% of collagen deposition (p = 0.007), reduction of 21.3% in N-acetylglucosaminidase activity (p &lt; 0.001), and increase of 246.7% of catalase activity (p = 0.002) without changes in reactive oxygen species (p = 0.518) and tissue lipid peroxidation (p = 0.664). All observed changes are attributed to the poor glycemic control (471.20 \u00b1 16.91 versus 80.00 \u00b1 3.42 mg\/dL (p &lt; 0.001)), which caused defective tissue regeneration and increased catalase activity as a compensatory mechanism. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0609","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T21:38:23Z","timestamp":1585949903000},"page":"490-497","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Thirty-day experimental diabetes impairs contractility and increases fatigue resistance in rat diaphragm muscle associated with increased anti-oxidative activity"],"prefix":"10.1139","volume":"98","author":[{"given":"Jo\u00e3o Victor Capelli","family":"Peixoto","sequence":"first","affiliation":[{"name":"Department of Physiology, Federal University of Paran\u00e1, Av. Francisco H. dos Santos 100, Jardim das Am\u00e9ricas, Curitiba, Paran\u00e1 81531-980, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Ant\u00f4nio S\u00e9rgio Rocha","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Federal University of Paran\u00e1, Av. Francisco H. dos Santos 100, Jardim das Am\u00e9ricas, Curitiba, Paran\u00e1 81531-980, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Rita","family":"Corso","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of Paran\u00e1, Av. Francisco H. dos Santos 100, Jardim das Am\u00e9ricas, Curitiba, Paran\u00e1 81531-980, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio Santos","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Federal Rural University of the Semi-Arid, Av. Francisco Mota 572, Pres. 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