{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:47:52Z","timestamp":1762253272331,"version":"3.41.0"},"reference-count":19,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p> Herpetotriol, a typical lignan in Herpetospermum pedunculosum Wall\u2019s seeds that has long been used to treat icterhepatitis and indigestion and other related diseases in Tibet, is of potential hepatoprotection. This study aims to study the pharmacokinetics features of herpetotriol, including the blood drug concentration\u2009\u2013\u2009time curve and tissue distribution. The ultrahigh-performance liquid chromatography with tandem mass spectrometry method was established to detect herpetotriol concentration in plasma and tissues, and the method showed good linearity from 10 to 2000 ng\/mL (r \u2265 0.9972) and sensitivity (\u226510 ng\/mL). Our blood drug concentration\u2009\u2013\u2009time curve indicated that herpetotriol was distributed quickly in rats with a T<jats:sub>max<\/jats:sub> value at about 0.083 h and eliminated rapidly with a clearance rate at 98.13 \u00b1 8.05 and 137.04 \u00b1 9.48 L\u00b7h<jats:sup>\u20131<\/jats:sup>\u00b7kg<jats:sup>\u20131<\/jats:sup> with doses of 5 and 2.5 mg\/kg, respectively. Although herpetotriol was detectable in all tested tissues, it has a higher concentration in liver than in heart, lung, spleen, and kidney, which is in line with its hepatoprotection. The pharmacokinetics features uncovered by the present study could provide more information for future pharmacological and toxicological study of herpetotriol. <\/jats:p>","DOI":"10.1139\/cjpp-2019-0633","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T21:35:40Z","timestamp":1580765740000},"page":"366-372","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacokinetics and tissue distribution study of herpetotriol in rats by ultrahigh-performance liquid chromatography with tandem mass spectrometry"],"prefix":"10.1139","volume":"98","author":[{"given":"Zhaoyue","family":"Dong","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Otorhinolaryngology, Chongqing Health Center for Women and Children, Chongqing 400013, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqing","family":"Deng","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingqiu","family":"Ge","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Quan","sequence":"additional","affiliation":[{"name":"TAAHC-SWU Medicinal Plant R&D Center, XiZang Agriculture and Animal Husbandry College, Nyingchi, Tibet, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhong","family":"Lan","sequence":"additional","affiliation":[{"name":"TAAHC-SWU Medicinal Plant R&D Center, XiZang Agriculture and Animal Husbandry College, Nyingchi, Tibet, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southwest University, Chongqing 400715, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.01.003"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.13593\/j.cnki.51-1501\/r.2008.03.012"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.07.024"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010014"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.11.039"},{"key":"refg7\/ref7","unstructured":"Jiang, X. 2010. Protective effect of extracting solution of the Tibetan medicine Herpetospermum pedunculosum seeds on acute liver injury mice produced by carbon tetrachloride. 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