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This was done for the first time by tracking different biochemical parameters that reflect rat heart antioxidative and oxidative capacities, nitric oxide and arginine metabolism, and the glutathione cycle. Additionally, the extrinsic apoptosis pathway related parameters were studied. Acute exposure to CCl<jats:sub>4<\/jats:sub> led to an increase in the studied tissue oxidant parameters (hydrogen peroxide, malondialdehyde, and carbonylated protein content), as well as the activity alteration of antioxidant (catalase, superoxide dismutase, and peroxidase) and glutathione-metabolizing (glutathione peroxidase, S-transferase, and reductase) enzymes. Furthermore, CCl<jats:sub>4<\/jats:sub> caused a disturbance in the tissue myeloperoxidase, nitric oxide, citrulline, arginase, and inducible nitric oxide synthase content and activities and in two apoptosis-related parameters, caspase-3 and FAS ligand. Melatonin as a post-treatment prevented the changes induced by CCl<jats:sub>4<\/jats:sub> to a differing extent, and in some cases, it was so potent that it completely abolished any tissue disturbances. This study is a promising starting point for further research directed to the development of melatonin treatment in cardiac tissue associated diseases. <\/jats:p>","DOI":"10.1139\/cjpp-2020-0201","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T17:36:11Z","timestamp":1596735371000},"page":"360-367","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Melatonin modulates acute cardiac muscle damage induced by carbon tetrachloride \u2014 involvement of oxidative damage, glutathione, and arginine and nitric oxide metabolism"],"prefix":"10.1139","volume":"99","author":[{"given":"Snezana","family":"\u0106iri\u0107 Zdravkovi\u0107","sequence":"first","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Center Ni\u0161, University of Ni\u0161, Ni\u0161, Serbia."},{"name":"Faculty of Medicine, University of Ni\u0161, Ni\u0161, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomislav","family":"Kosti\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Center Ni\u0161, University of Ni\u0161, Ni\u0161, Serbia."},{"name":"Faculty of Medicine, University of Ni\u0161, Ni\u0161, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran P.","family":"Marceti\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana S.","family":"\u0160ulovi\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biserka M.","family":"Nedeljkovi\u0107","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adem","family":"Preljevi\u0107","sequence":"additional","affiliation":[{"name":"State University of Novi Pazar, Novi Pazar, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Toski\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Physical Education Leposavic, University of Pristina, Pristina, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du\u0161an","family":"Sokolovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ni\u0161, Ni\u0161, Serbia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2013.09.006"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1080\/08860220600683631"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1038\/srep18065"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14048638"},{"key":"refg5\/ref5","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0076-6879(55)02300-8","volume":"2","author":"Chance B.","year":"1955","journal-title":"Methods Enzymol."},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2018.1517182"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1177\/1559325818790158"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5857940"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2014.03.001"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1066398"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(91)90067-M"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08546-1"},{"issue":"9","key":"refg14\/ref14","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.4049\/jimmunol.161.9.4695","volume":"161","author":"Ishiyama S.","year":"1998","journal-title":"J. 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