{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:39:15Z","timestamp":1791646755704,"version":"4.3.4"},"reference-count":30,"publisher":"Canadian Science Publishing","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p> Oleuropein (OLE) is the main bioactive ingredient in the leaves of the olive plant Olea europaea L. (Oleaceae), which has proven beneficial due to the antiinflammatory, antiatherogenic, anticancer, antimicrobial, and antiviral effects. This study aimed to investigate the antihypertensive and vasodilator potential of OLE by analyzing its acute effects on spontaneous atrial contractions and vasomotor responses of the isolated thoracic aorta in rats. We showed that the application of OLE induces negative chronotropic and inotropic effects on the heart. OLE also causes mild aortic vasodilation given that the maximal reduction in tension of intact aortic rings precontracted with phenylephrine was approximately 30%. This vasodilation is likely dependent on the nitric oxide released from the endothelium based on the effect obtained on denuded and phenylephrine precontracted aortic rings and responses reordered following vasoconstriction induced by high concentrations of K<jats:sup>+<\/jats:sup> and heparin. Our findings provide a basis for further testing of OLE cardiovascular effects, which may lead to subsequent clinical research for its application in the treatment of hypertension and heart disease. <\/jats:p>","DOI":"10.1139\/cjpp-2020-0363","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T17:57:42Z","timestamp":1610733462000},"page":"110-114","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of oleuropein on rat\u2019s atria and thoracic aorta: a study of antihypertensive mechanisms"],"prefix":"10.1139","volume":"99","author":[{"given":"Sonja","family":"Ilic","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Ni\u0161, Blvd dr Zorana Djindjica 81, Ni\u0161, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Stojiljkovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Ni\u0161, Blvd dr Zorana Djindjica 81, Ni\u0161, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Ni\u0161, Blvd dr Zorana Djindjica 81, Ni\u0161, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Stoiljkovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Ni\u0161, Blvd dr Zorana Djindjica 81, Ni\u0161, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Mitic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ni\u0161, Blvd dr Zorana Djindjica 81, Ni\u0161, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Salinger-Martinovic","sequence":"additional","affiliation":[{"name":"Clinic for Cardiovascular Diseases, Clinical Center Ni\u0161, Blvd dr Zorana Djindjica 48, Ni\u0161, Serbia."},{"name":"Department of Cardiology, Faculty of Medicine, University of Ni\u0161, Blvd dr Zorana Djindjica 81, Ni\u0161, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavle","family":"Randjelovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Ni\u0161, Blvd dr Zorana Djindjica 81, Ni\u0161, Serbia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.8.2213"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.11.016"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1089\/109662002753723160"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000062884.69432.A0"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.04.026"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00320-7"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01218-8"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-78-9-714"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200102000-00008"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-018-3398-1"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.17179\/excli2017-1002"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1021\/jf901280r"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1207"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.08.015"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000109436"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2003.12.010"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/908493"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.2298\/VETGL1306303M"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/247054"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.2008.01008.x"},{"key":"refg22\/ref22","doi-asserted-by":"crossref","unstructured":"Rang, H.P., and Dale, M.M. 2007. 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