{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:25:51Z","timestamp":1773199551859,"version":"3.50.1"},"reference-count":45,"publisher":"Canadian Science Publishing","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p> Oxycodone, a semisynthetic opioid analgesic with actions similar to morphine, is extensively prescribed for treatment of moderate to severe acute pain. Given that glutamate plays a crucial role in mediating pain transmission, the purpose of this study was to investigate the effect of oxycodone on glutamatergic synaptic transmission in rat hippocampal CA3 area, which is associated with the modulation of nociceptive perception. Whole-cell patch-clamp recordings revealed that oxycodone effectively reduced presynaptic glutamate release, as detected by decreased frequencies of spontaneous excitatory postsynaptic currents (sEPSCs) and miniature EPSCs (mEPSCs), without eliciting significant changes in the amplitudes of sEPSCs and mEPSCs and glutamate-evoked inward currents. The inhibitory effect of oxycodone on the frequency of sEPSCs was blocked by the nonselective opioid receptor antagonist naloxone. In addition, oxycodone suppressed burst firing induced by 4-aminopyridine and tonic repetitive firing evoked by the applied depolarizing current. These results suggest that oxycodone inhibits spontaneous presynaptic glutamate release possibly by activating opioid receptors and consequently suppressing the neuronal excitability of hippocampal CA3 neurons. <\/jats:p>","DOI":"10.1139\/cjpp-2020-0469","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T16:41:41Z","timestamp":1605112901000},"page":"737-743","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of glutamatergic transmission and neuronal excitability by oxycodone in the rat hippocampal CA3 neurons"],"prefix":"10.1139","volume":"99","author":[{"given":"Cheng-Wei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei 22060, Taiwan."},{"name":"Department of Mechanical Engineering, Yuan Ze University, Taoyuan 32003, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei 22060, Taiwan."},{"name":"Department of Mechanical Engineering, Yuan Ze University, Taoyuan 32003, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Kuei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei 22060, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Ming","family":"Chiu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Cardiovascular Center, Far-Eastern Memorial Hospital, New Taipei 22060, Taiwan."},{"name":"Department of Nursing, Oriental Institute of Technology, New Taipei 22060, Taiwan."},{"name":"Department of Photonics Engineering, Yuan Ze University, Taoyuan 32003, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Cardiovascular Center, Far-Eastern Memorial Hospital, New Taipei 22060, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jih-Hsin","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Cardiovascular Center, Far-Eastern Memorial Hospital, New Taipei 22060, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Jane","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Fu Jen Catholic University, New Taipei 24205, Taiwan."},{"name":"Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-003-0218-x"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(00)00053-8"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb06048.x"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.014"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.09.012"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12345"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.01.072"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02660.2002"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03660.x"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1124\/mol.117.110775"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.01.010"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03222-8"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet337"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.06.012"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(10)70316-9"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1038\/357134a0"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1038\/355050a0"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903500307"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00255.x"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.6.2878"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.4.1007S"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02139.x"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.03.022"},{"key":"refg45\/ref45","unstructured":"NIH. 2011. 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