{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:39:34Z","timestamp":1759563574554,"version":"3.41.0"},"reference-count":38,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p> Cardiac damage during the acute phase of Chagas disease (CD) is associated with an increase in pro-inflammatory markers and oxidative stress. Melatonin (MEL) has emerged as a promising therapy for CD due to its antioxidant and immunomodulatory properties; however, the protective action of MEL in the cardiac tissue, as well as its direct action on the parasite cycle, is not fully understood. We investigated the effects of MEL on heart parasitism in mice infected with Trypanosoma cruzi and also its effects on the parasitic proliferation in vitro. Our in vivo study showed that MEL reduced circulating parasitemia load, but did not control tissue (heart, liver, and spleen) parasitism in mice. MEL did not prevent the redox imbalance in the left ventricle of infected mice. Our in vitro findings showed that MEL did not inhibit parasites replication within cells, but rather increased their release from cells. MEL did not control parasitism load in the heart or prevent the cardiac redox imbalance induced by acute T.\u00a0cruzi infection. The hormone controlled the circulating parasitic load, but within cells MEL accelerated parasitic release, a response that can be harmful. <\/jats:p>","DOI":"10.1139\/cjpp-2020-0473","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T21:39:43Z","timestamp":1607549983000},"page":"795-802","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Melatonin decreases circulating <i>Trypanosoma cruzi<\/i> load with no effect on tissue parasite replication"],"prefix":"10.1139","volume":"99","author":[{"given":"Maiara Voltarelli","family":"Providello","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, DACTB, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Bulh\u00f5es","family":"Portapilla","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, DACTB, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Alexandre Sampaio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, DACTB, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Brigag\u00e3o Pacheco","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia, DEPCH, Escola de Enfermagem de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naira Ferreira","family":"Anchieta","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, DACTB, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Renato","family":"Tirapelli","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia, DEPCH, Escola de Enfermagem de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, DACTB, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.08.037"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.11.018"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12409"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12510"},{"key":"refg6\/ref6","first-page":"389","volume":"4","author":"Brener Z.","year":"1962","journal-title":"Rev. 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