{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T03:24:28Z","timestamp":1772249068811,"version":"3.50.1"},"reference-count":66,"publisher":"Canadian Science Publishing","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"abstract":"<jats:p> N-acetylcysteine (NAC) and melatonin were reported to exert protective effects on testicular tissues. Thus, this study aimed to determine which of these is more efficient against obesity-induced testicular dysfunction in albino rats. A total of 32 adult male rats (195\u00a0\u00b1 10\u00a0g) were divided into four groups: control, obese rats fed a high-fat diet (HFD), HFD+NAC (150\u00a0mg\/kg per day, i.p.) and HFD+melatonin (10\u00a0mg\/kg per day, i.p.), for 5 weeks. Testes and epididymis were weighed. Lipid profile, pituitary-testicular hormones, tumor necrosis factor \u03b1 (TNF\u03b1), epididymal sperm parameters, testicular oxidant\u2013antioxidant system, testicular and the epididymal histopathology and immunohistochemical localization for androgen receptors (AR) and Bax reaction were analyzed. Administration of NAC or melatonin significantly improved the lipid parameters, gonadal hormones, TNF\u03b1 level, sperm count and abnormal morphology, oxidant\u2013antioxidant system and the absolute testicular and epididymal mass with an enhancement of testicular architecture, AR expression and apoptosis as compared with that in the obese group. Additionally, as compared with the NAC group, the melatonin group had significantly reduced body mass index, total cholesterol, triglyceride, and TNF\u03b1 and increased testosterone, sperm count, motility, superoxide dismutase activity, mitigated histomorphometrical changes, Bax expression, and increased testicular AR expression. Therefore, melatonin was more efficient than NAC in affording fortification against HFD-induced testicular dysfunction. <\/jats:p>","DOI":"10.1139\/cjpp-2020-0499","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T21:40:56Z","timestamp":1605649256000},"page":"1-12","source":"Crossref","is-referenced-by-count":13,"title":["Comparative protective effects of <i>N<\/i>-acetylcysteine and melatonin against obesity-induced testicular dysfunction in rats"],"prefix":"10.1139","author":[{"given":"Sama S.","family":"Khalil","sequence":"first","affiliation":[{"name":"Medical Physiology Department, Faculty of Medicine, Zagazig University, Al-Sharquia, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Amin","family":"Aziz","sequence":"additional","affiliation":[{"name":"Human Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Al-Sharquia, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadiga Ahmed","family":"Ismail","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Science Department, College of Applied Medical Sciences, Taif, Saudi Arabia."},{"name":"Medical Parasitology Department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanees F.","family":"El-Malkey","sequence":"additional","affiliation":[{"name":"Medical Physiology Department, Faculty of Medicine, Zagazig University, Al-Sharquia, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/836121"},{"key":"refg2\/ref2","unstructured":"Bancroft, J.D., and Gamble, M. 2008. 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