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In this study, we observed the possible effects of KBrO<jats:sub>3<\/jats:sub> on oxidative stress and inflammatory biomarkers in sodium hydroxide (NaOH) \u2013 induced Crohn\u2019s colitis (CC). Wistar rats (180\u2013200 g) were divided into six groups (n = 10): (i) control; (ii) untreated CC (induced by 1.4% NaOH; intra-rectal administration); and (iii\u2013vi) CC treated with vitamin E, KBrO<jats:sub>3<\/jats:sub>, vitamin E+KBrO<jats:sub>3<\/jats:sub>, and sulphazalazine, respectively, for 7 days. Body weight and stool score were monitored daily. By day 3 and 7, excised colon was evaluated for ulcer scores and biochemical and histological analysis. Blood samples collected on days 3 and 7 were assayed for haematological indices using standard methods. Data were subjected to analysis of variance (ANOVA) and p \u2264 0.05 considered significant. Platelet\/lymphocyte ratio, colonic ulcer score, malondialdehyde, and mast cells were significantly decreased while colonic sulfhydryl, and Ca<jats:sup>2+<\/jats:sup>- and Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase activities were increased following KBrO<jats:sub>3<\/jats:sub> treatment compared with untreated CC. These findings suggest that KBrO<jats:sub>3<\/jats:sub> may mitigate against NaOH-induced CC via inhibiting mast cell population and oxidative and inflammatory content but stimulating colonic sulfhydryl and Ca<jats:sup>2+<\/jats:sup>- and Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>-ATPase activities. <\/jats:p>","DOI":"10.1139\/cjpp-2020-0678","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T21:49:41Z","timestamp":1618350581000},"page":"989-999","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Potassium bromate (KBrO<sub>3<\/sub>) modulates oxidative stress and inflammatory biomarkers in sodium hydroxide (NaOH) \u2013 induced Crohn\u2019s colitis in Wistar rats"],"prefix":"10.1139","volume":"99","author":[{"given":"Adeola Temitope","family":"Salami","sequence":"first","affiliation":[{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."},{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Enevwo","family":"Okotie","sequence":"additional","affiliation":[{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."},{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Precious Nekachi","family":"Echendu","sequence":"additional","affiliation":[{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."},{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwaifoh","family":"Akpamu","sequence":"additional","affiliation":[{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."},{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Babafemi","family":"Olaleye","sequence":"additional","affiliation":[{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."},{"name":"Gastrointestinal secretions and inflammation research unit, Department of Physiology, University of Ibadan, Ibadan, Oyo State, Nigeria."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.21767\/2248-9215.100027"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-013-1563-4"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119137"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2017.01.060"},{"issue":"6","key":"refg5\/ref5","first-page":"367","volume":"9","author":"Ananthakrishnan A.N.","year":"2013","journal-title":"Gastroenterol. 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