{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:19:09Z","timestamp":1775611149879,"version":"3.50.1"},"reference-count":49,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p> Beta-caryophyllene (BCP), a cannabinoid 2 (CB<jats:sub>2<\/jats:sub>) receptor agonist has recently been found to have cardioprotective activity as an anti-inflammatory and antioxidant molecule. L-arginine (LA), a nitric oxide (NO) donor, is a potential regulator of cardiovascular function. Considering the role of CB<jats:sub>2<\/jats:sub> receptor activation and NO regulation in cardiovascular diseases, the combination of BCP with LA may be a possible treatment of diabetic cardiomyopathy (DCM). Hence, we investigated the efficacy of the novel combination of BCP with LA on cardiovascular inflammation and oxidative stress in diabetic rats. DCM was induced by streptozotocin (55 mg\/kg) in Sprague\u2013Dawley rats intraperitoneally. BCP, LA, and BCP with LA were administered to diabetic rats for 4 weeks. After completion of the study, hemodynamic parameters, biochemical parameters, and inflammatory cytokine levels were analyzed. Also, oxidative stress parameters, nuclear factor kappa beta (NF-\u0138\u03b2) expression, and histopathology in cardiac tissues were estimated. The combination of BCP (200 mg\/kg) with LA (200 mg\/kg) significantly normalized the hemodynamic parameters and decreased the glucose, cardiac markers, interleukin-6, and tumor necrosis factor-alpha levels. Treatment of BCP and LA showed a significant decrease in oxidative stress and downregulated the cardiac expression of NF-\u0138\u03b2. Thus, the combination of BCP with LA improves cardiac functions by attenuating inflammation through NF-\u0138\u03b2 inhibition in DCM. <\/jats:p>","DOI":"10.1139\/cjpp-2021-0046","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T21:35:44Z","timestamp":1638567344000},"page":"259-271","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-\u0138\u03b2 inhibition"],"prefix":"10.1139","volume":"100","author":[{"given":"Vivek S.","family":"Kumawat","sequence":"first","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM\u2019s NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai- 400056, India."},{"name":"Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM\u2019s NMIMS, V. L. 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