{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:52:53Z","timestamp":1790373173873,"version":"4.1.0"},"reference-count":82,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p> The object of this study was to evaluate the relationship between oxidative damage induced by oxaliplatin (OXA) and the therapeutic potential of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) in kidney of mice. Mice received OXA (10\u00a0mg\/kg) or vehicle intraperitoneally (days\u00a00 and 2). Oral administration of 4-PSQ (1\u00a0mg\/kg) or vehicle was performed on days\u00a02 to 14. On day\u00a015 the animals were euthanized and the kidneys and blood were collected. The effect of OXA and (or) 4-PSQ on urea, thiobarbituric acid reactive species, nonprotein thiol (NPSH), and protein carbonyl (PC) levels were investigated. Moreover, renal superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), \u03b4-aminolevulinic acid dehydratase (\u03b4-ALA-D), and Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup> ATPase activities were evaluated. Our findings revealed an increase on urea levels and significant renal oxidative damage in OXA-induced mice. OXA exposure increased SOD, GPx, and GST activities and caused a reduction on NPSH levels and CAT and GR activities. Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup> ATPase and \u03b4-ALA-D activities were reduced by OXA. 4-PSQ decreased plasmatic urea levels and renal oxidative damage. SOD, GPx, CAT, GR, and Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup> ATPase activities were restored by 4-PSQ. 4-PSQ may be a good prototype for the treatment of OXA-induced renal injury. <\/jats:p>","DOI":"10.1139\/cjpp-2021-0090","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T21:35:44Z","timestamp":1621546544000},"page":"1102-1111","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["7-Chloro-4-(phenylselanyl) quinoline reduces renal oxidative stress induced by oxaliplatin in mice"],"prefix":"10.1139","volume":"99","author":[{"given":"Ketlyn P.","family":"da Motta","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Farmacologia Bioqu\u00edmica \u2013 LaFarBio, CCQFA - Universidade Federal de Pelotas, UFPel, P.O. Box 354 - 96010-900, Pelotas, RS, Brazil."},{"name":"Curso de Bacharelado em Qu\u00edmica Forense, Centro de Ci\u00eancias Qu\u00edmicas, Farmac\u00eauticas e de Alimentos - Universidade Federal de Pelotas, UFPel, P.O. CEP 96010-900 Pelotas, RS, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briana B.","family":"Lemos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Farmacologia Bioqu\u00edmica \u2013 LaFarBio, CCQFA - Universidade Federal de Pelotas, UFPel, P.O. Box 354 - 96010-900, Pelotas, RS, Brazil."},{"name":"Curso de Bacharelado em Qu\u00edmica Forense, Centro de Ci\u00eancias Qu\u00edmicas, Farmac\u00eauticas e de Alimentos - Universidade Federal de Pelotas, UFPel, P.O. 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