{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:57:51Z","timestamp":1768485471542,"version":"3.49.0"},"reference-count":42,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p> Nanoparticles (NPs) have many toxic effects on fertility and can prevent successful implantation by affecting the maternal uterine tissue. Herein, by deploying 30 female NMRI mice, the effect of silver NPs on the endometrium and implantation has been investigated. Using spherical silver NPs of a diameter of 18\u201330 nm at doses of 2 and 4 mg\/kg, mice in two groups were treated. Then, female mice mated with male mice. Endometrial tissue was extracted 4.5 days later. On the fourth day of pregnancy, the mice were anesthetized and blood samples were taken from the heart; furthermore, endometrial tissue was isolated and used for molecular tests, inductively coupled plasma, and examination of pinopods. The results revealed that the levels of interleukin 6 (IL-6) and IL-1\u03b2 and the accumulation of NPs in endometrial tissue in the group receiving NPs at a dose of 4 mg\/kg had a major increase relative to the other two groups (p &lt; 0.05); the group receiving a dose of 4 mg\/kg exhibited a decrease in pinopods and microvillus compared with the other two groups. According to the results, NPs can reach the endometrium, suggesting that caution should be exercised due to serious exposure to NPs throughout pregnancy. <\/jats:p>","DOI":"10.1139\/cjpp-2021-0094","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T21:47:41Z","timestamp":1626817661000},"page":"1264-1271","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Toxicity of silver nanoparticles on endometrial receptivity in female mice"],"prefix":"10.1139","volume":"99","author":[{"given":"Marziyeh","family":"Ajdary","sequence":"first","affiliation":[{"name":"Student Research Committee, Iran University of Medical Sciences, Tehran, Iran."},{"name":"Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Eghbali","sequence":"additional","affiliation":[{"name":"Department of Anatomical Science, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid Pirhajati","family":"Mahabadi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Vice-Chancellor for Research and Technology, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariborz","family":"Keyhanfar","sequence":"additional","affiliation":[{"name":"Student Research Committee, Iran University of Medical Sciences, Tehran, Iran."},{"name":"Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajender S.","family":"Varma","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, \u0160lechtitel\u016f 27, 783 71 Olomouc, Czech Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8090634"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-019-00310-2"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2011.626539"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2010.153"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1021\/nn302502u"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs008"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7439.1000225"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0970083"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483x(93)90073-2"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041233"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072375"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.09.006"},{"key":"refg13\/ref13","first-page":"228","volume":"8","author":"Ghorbanzadeh V.","year":"2011","journal-title":"Middle East J. 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