{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:49:26Z","timestamp":1762660166303,"version":"3.41.0"},"reference-count":52,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p> In this study, we investigated the blood pressure responses of the peripheral bed in\u00a0vivo after chronic hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) inhibition combined with acute nitric oxide (NO) deficiency. We also evaluated the role of endogenously produced H<jats:sub>2<\/jats:sub>S in the vasoactive responses of large- and medium-sized arteries in\u00a0vitro. Changes in integrated blood pressure responses were measured after chronic inhibition of cystathionine-\u03b3-lyase, an enzyme involved in H<jats:sub>2<\/jats:sub>S synthesis, with DL-propargylglycine (PPG), and acute inhibition of NO-synthase with nonspecific L-N<jats:sup>G<\/jats:sup>-nitro arginine methyl ester (L-NAME), and vasoactive responses of the thoracic aorta (TA) and mesenteric artery (MA) were investigated after acute incubation with PPG. We confirmed that chronic H<jats:sub>2<\/jats:sub>S deficiency had no effect on blood pressure, heart trophycity, noradrenaline, and H<jats:sub>2<\/jats:sub>S donor vasoactive responses but induced renal hypertrophy and a decrease in acetylcholine-induced hypotensive and L-NAME-induced hypertensive responses. Acute H<jats:sub>2<\/jats:sub>S deficiency led to an increase in basal tone (MA) or active tone (TA), whereas endothelium-dependent vasorelaxation remained unaffected. Long-term administration of PPG revealed a role of endogenous H<jats:sub>2<\/jats:sub>S in the bioavailability of endothelial NO in peripheral arteries. When both H<jats:sub>2<\/jats:sub>S and NO were lacking, the activation of H<jats:sub>2<\/jats:sub>S-independent compensatory mechanisms plays an important role in maintaining the vasodilator responses of the cardiovascular system. <\/jats:p>","DOI":"10.1139\/cjpp-2021-0251","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T21:33:03Z","timestamp":1643751183000},"page":"464-472","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats"],"prefix":"10.1139","volume":"100","author":[{"given":"Magdalena","family":"Drobna","sequence":"first","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic."},{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Berenyiova","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic."},{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sona","family":"Cacanyiova","sequence":"additional","affiliation":[{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic."},{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12171"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2014.12.008"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2018.4.05"},{"issue":"4","key":"refg5\/ref5","first-page":"501","volume":"67","author":"Cacanyiova S.","year":"2016","journal-title":"J. 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