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In addition, the sensitivity of the BR changes under the influence of hormones, in particular glucocorticoids (GCs). It has been suggested that GCs may influence BRS by altering the ability of the IC to modulate the BR. This hypothesis has been tested in experiments on rats anesthetized with urethane. It was found that microelectrostimulation of the visceral area in the left IC causes a short-term drop in AP, which is accompanied by bradycardia and impairs BRS. The synthetic GC dexamethasone (DEX) did not significantly affect the magnitude of depressor responses but increased BRS and impaired the effect of IC stimulation on the BR. The results obtained confirm the hypothesis put forward and suggest that GC can attenuate the inhibitory effects of the IC on the BR arc, thereby enhancing the sensitivity of the BR. <\/jats:p>","DOI":"10.1139\/cjpp-2021-0385","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:38:42Z","timestamp":1634161122000},"page":"334-340","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat"],"prefix":"10.1139","volume":"100","author":[{"given":"Tatiana S.","family":"Tumanova","sequence":"first","affiliation":[{"name":"Pavlov Institute of Physiology RAS, 6, nab. Makarova, Saint-Petersburg 199034, Russia."},{"name":"Herzen State Pedagogical University of Russia, 48, nab. 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