{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T22:21:50Z","timestamp":1769206910446,"version":"3.49.0"},"reference-count":46,"publisher":"Canadian Science Publishing","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["8186072"],"award-info":[{"award-number":["8186072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:p> Periodontitis is an inflammatory disease of the gums. Periodontitis in diabetic patients can aggravate insulin resistance; however, its molecular and biological mechanism remains unclear. This study aimed to explore the effects of diabetic periodontitis on liver function and determine the mechanism by which artesunate improves liver function. Rats with streptozotocin-induced diabetes were divided into five groups: normal control (NC), diabetic periodontitis (DM\u00a0+\u00a0PD), artesunate intervention (ART), insulin intervention (INS), and combined medication intervention (ART\u00a0+\u00a0INS) groups. Drug interventions were then administered to the rats in each group as follows: 50\u00a0mg\/kg artesunate to the ART group, 6\u00a0U\/kg insulin to the INS group, and 50\u00a0mg\/kg artesunate + 6\u00a0U\/kg insulin to the ART\u00a0+\u00a0INS group. Blood samples, liver tissues, and the maxillary alveolar bone were collected postsacrifice. ART was found to significantly ameliorate hyperglycemia, blood lipid concentrations, and liver function. The levels of inflammatory factors reduced; the effect was more pronounced in the ART\u00a0+\u00a0INS group. Artesunate presumably inhibits the TLR4\/NF-\u03baB signaling pathway and expression of downstream inflammatory factors, thereby exerting a protective effect on diabetes-related liver function. This offers a fresh approach to treat diabetes mellitus. <\/jats:p>","DOI":"10.1139\/cjpp-2021-0665","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T17:33:25Z","timestamp":1651512805000},"page":"741-754","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis"],"prefix":"10.1139","volume":"100","author":[{"given":"Shuoqiu","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery","place":["Nanning, China"]},{"name":", College of Stomatology, Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery","place":["Nanning, China"]},{"name":", College of Stomatology, Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8900-9057","authenticated-orcid":false,"given":"Xiaolin","family":"Nong","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery","place":["Nanning, China"]},{"name":", College of Stomatology, Guangxi Medical University","place":["Nanning, China"]},{"name":"Guangxi Key Laboratory of Oral and Maxillofacial Surgery Disease Treatment","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongkang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery","place":["Nanning, China"]},{"name":", College of Stomatology, Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery","place":["Nanning, China"]},{"name":", College of Stomatology, Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chubin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery","place":["Nanning, China"]},{"name":", College of Stomatology, Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaquan","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Science Research Center Guangxi Medical University","place":["Nanning, China"]},{"name":"Life Science Institute","place":["Nanning, China"]},{"name":"Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.06.017"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309897"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406392200"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-019-00403-4"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2017.73"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1817"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i4.50"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26319"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.07.012"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.1465"},{"issue":"2","key":"refg13\/ref13","first-page":"108","volume":"44","author":"Kheiripour N.","year":"2019","journal-title":"J. Med. Sci."},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1089\/met.2018.0003"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900146R"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.03.014"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.1.329"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0797-5"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-388"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1590\/1678-77572016-0302"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10070290"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01960-7"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2005.07.009"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030686"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01955"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2016.12.011"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.7326\/ACPJ201904160-040"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12929"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5659"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2019.114846"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.100643"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.08.036"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1002\/med.21580"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.07.011"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0044-y"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1009.2016.00005"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3593951"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242008000500006"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.11.080"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-16"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000433"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-015-0328-1"},{"key":"refg43\/ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0289-6"},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049257"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1052-x"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164838"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2021-0665","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2021-0665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:22:20Z","timestamp":1754482940000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2021-0665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,1]]}},"alternative-id":["10.1139\/cjpp-2021-0665"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2021-0665","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,1]]},"assertion":[{"value":"2022-05-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}