{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:53:02Z","timestamp":1762782782251,"version":"3.41.0"},"reference-count":54,"publisher":"Canadian Science Publishing","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:p> Besides the health benefits of regular exercise, high-level training\u2014above an optimal level\u2014may have adverse effects. In this study, we investigated the effects of long-term vigorous training and its potentially detrimental structural\u2013functional changes in a small animal athlete's heart model. Thirty-eight 4-month-old male guinea pigs were randomized into sedentary and exercised groups. The latter underwent a 15-week-long endurance-training program. To investigate the effects of the intense long-term exercise, in vivo (echocardiography, electrocardiography), ex vivo, and in vitro (histopathology, patch-clamp) measurements were performed. Following the training protocol, the exercised animals exhibited structural left ventricular enlargement and a significantly higher degree of myocardial fibrosis. Furthermore, resting bradycardia accompanied by elevated heart rate variability occurred, representing increased parasympathetic activity in the exercised hearts. The observed prolonged QTc intervals and increased repolarization variability parameters may raise the risk of electrical instability in exercised animals. Complex arrhythmias did not occur in either group, and there were no differences between the groups in ex vivo or cellular electrophysiological experiments. Accordingly, the high parasympathetic activity may promote impaired repolarization in conscious exercised animals. The detected structural\u2013functional changes share similarities with the human athlete's heart; therefore, this model might be useful for investigations on cardiac remodeling. <\/jats:p>","DOI":"10.1139\/cjpp-2022-0073","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T21:35:13Z","timestamp":1657834513000},"page":"993-1004","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model"],"prefix":"10.1139","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-6352","authenticated-orcid":false,"given":"L.","family":"Topal","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, University of Szeged","place":["Szeged, 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