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The byproducts of PLC hydrolytic activity, namely, 1,2-diacylglycerol and inositol-1,4,5-trisphosphate, are important downstream signal transducers for increased protein synthesis in the cardiomyocyte and the subsequent hypertrophic response. In this article, evidence was outlined to demonstrate the role of cardiomyocyte PLC isozymes in the catecholamine-induced increase in protein synthesis by using a blocker of \u03b1<jats:sub>1<\/jats:sub>-AR and an inhibitor of PLC. The discussion was focused on the \u03b1<jats:sub>1<\/jats:sub>-AR-Gq\u03b1-PLC-mediated hypertrophic signalling pathway from the viewpoint that it may compliment the other \u03b2<jats:sub>1<\/jats:sub>-AR-G<jats:sub>s<\/jats:sub> protein-adenylyl cyclase signal transduction mechanisms in the early stages of cardiac hypertrophy development, but may become more relevant at the late stage of cardiac hypertrophy. 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