{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:39:43Z","timestamp":1778837983037,"version":"3.51.4"},"reference-count":49,"publisher":"Canadian Science Publishing","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p> Cumulating evidence demonstrated that chronic intermittent hypobaric hypoxia (CIHH) had beneficial effects on the body. This study investigated the role of perivascular adipose tissue (PVAT) in ameliorating effect of CIHH on vascular reactivity by adiponectin in mesenteric artery of metabolic syndrome (MS) rats. Main methods: 6-week-old male Sprague-Dawley rats were randomly divided into four groups: control (CON), MS model, CIHH treatment, and MS\u00a0+\u00a0CIHH treatment group. The size of adipocytes in PVAT was measured by scanning electron microscopy. Serum adiponectin was measured. The microvessel recording technique was used to observe the effect of CIHH on contraction and relaxation in mesenteric artery rings. Also, the expressions of interleukin-1\u03b2, tumor necrosis factor-\u03b1, adiponectin, AdipoR1, AdipoR2, APPL1, and endothelial nitric oxide synthase (eNOS) were assayed by Western blotting. Key findings: in MS rats, adipocyte size increased, serum adiponectin decreased, contraction reaction increased while relaxation reaction decreased, the expression of pro-inflammatory cytokines was upregulated, while adiponectin was downregulated in PVAT, and the expressions of AdipoR1, AdipoR2, APPL, and phosphorylated-eNOS were downregulated in mesenteric artery. All aforementioned abnormalities of MS were ameliorated in MS\u00a0+\u00a0CIHH rats. We concluded that CIHH treatment improves vascular reactivity through upregulating adiponectin expression and downregulating pro-inflammatory cytokine expression of PVAT in MS rats. <\/jats:p>","DOI":"10.1139\/cjpp-2022-0252","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T16:34:21Z","timestamp":1675096461000},"page":"160-170","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats"],"prefix":"10.1139","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8746-2424","authenticated-orcid":false,"given":"Fang","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Physiology, Hebei Medical University","place":["Shijiazhuang, P.R. China"]},{"name":"Department of Electron Microscope Laboratory, Hebei Medical University","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haichao","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Electron Microscope Laboratory, Hebei Medical University","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruotong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanming","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaifan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Hebei Medical University","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University","place":["Shijiazhuang, P.R. China"]},{"name":"Hebei Collaborative Innovation Center for Cardio-cerebrovascular Disease","place":["Shijiazhuang, P.R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.09.021"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00051"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.52"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/164_2021_558"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.10.014"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.182998"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1580"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.05.008"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00013"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.205"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1002\/tsm2.254"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2017.05.004"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13126"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0171"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328330a900"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.054"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken386"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000220381.40739.dd"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000002840"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.05.028"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.821181"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.05.028"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01395.x"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030698"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.1038\/nature08991"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.11.004"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041951"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2014.07.002"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.01.023"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.11"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.04.053"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.138305"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001133"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0147"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00018.2019"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0777-x"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.09.064"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833c20d5"},{"key":"refg39\/ref39","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.239"},{"key":"refg40\/ref40","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2021.1991942"},{"key":"refg41\/ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.06.021"},{"key":"refg42\/ref42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402367200"},{"key":"refg43\/ref43","first-page":"3471447","volume":"2022","author":"Wang Q.","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"refg44\/ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1580-2"},{"key":"refg45\/ref45","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/473978"},{"key":"refg46\/ref46","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2020.04.08"},{"key":"refg47\/ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.11.019"},{"key":"refg48\/ref48","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0059"},{"key":"refg49\/ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.11.003"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2022-0252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2022-0252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:18:52Z","timestamp":1754482732000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2022-0252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,1]]}},"alternative-id":["10.1139\/cjpp-2022-0252"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2022-0252","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]},"assertion":[{"value":"2023-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}