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Also, essential oils may enhance immune function and surveillance, induce enzymes, enhance detoxification, and modulate multidrug resistance. Hemp oil, obtained from Cannabis sativaL. seeds, is known for its health-enhancing properties and bioactivity. Adult female Swiss albino mice were injected with viable Ehrlich ascites carcinoma cells (2.5\u00a0\u00d7 10<jats:sup>6<\/jats:sup> cells\/mouse), and then administered with hemp oil (20\u2009mg\/kg) daily for 10 consecutive days pre-, and then 10\u2009days post-exposure to 6\u2009Gy whole-body gamma irradiation. Hemp oil significantly increased Beclin1, VMP1, LC3, cytochrome c, and Bax. More interestingly, Hemp oil showed a significant decrease in Bcl2 and P13k either alone or in combination with \u03b3 radiation. Finally, this study documented the possible role of hemp oil in inducing two cell death types, autophagy and apoptosis, as it may be applied as an adjuvant in cancer treatment. <\/jats:p>","DOI":"10.1139\/cjpp-2022-0319","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T16:32:56Z","timestamp":1677083576000},"page":"226-234","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Delving into the death signaling pathway of hemp oil and gamma radiation in solid tumor bearing mice"],"prefix":"10.1139","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-6278","authenticated-orcid":false,"given":"A.A.","family":"Hassan","sequence":"first","affiliation":[{"name":"Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA)","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-3936","authenticated-orcid":false,"given":"S.Z.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA)","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-9017","authenticated-orcid":false,"given":"D.M.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA)","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3274-0209","authenticated-orcid":false,"given":"S.S.","family":"Abdelgayed","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Veterinary Medicine, Cairo University","place":["Giza, Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12041033"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5162687"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.3329\/bjp.v12i2.30892"},{"key":"refg4\/ref4","volume-title":"Theory and practice of histologic technique","author":"Bancroft D.","year":"2012","edition":"4"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2020.11.004"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1089\/can.2020.0001A"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-021-01687-9"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071935"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00370-08"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1648-4"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-42667-5_1"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1039\/C6NP00074F"},{"issue":"6","key":"refg13\/ref13","first-page":"1665","volume":"48","author":"Hassan A.A.","year":"2016","journal-title":"Pakistan J. 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