{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:09:03Z","timestamp":1758125343865,"version":"3.41.0"},"reference-count":53,"publisher":"Canadian Science Publishing","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:p> Inflammatory pathways of Toll-like receptor 4 (TLR4) and NLRP3 inflammasome contribute to acute myocardial infarction (AMI) pathophysiology. The hypoxia\u2010inducible factor 1\u03b1 (HIF-1\u03b1), however, is a key transcription factor related to cardioprotection. This study aimed to compare the influence of carvedilol and thyroid hormones (TH) on inflammatory and HIF-1\u03b1 proteins and on cardiac haemodynamics in the infarcted heart. Male Wistar rats were allocated into five groups: sham-operated group (SHAM), infarcted group (MI), infarcted treated with the carvedilol group (MI\u00a0+\u00a0C), infarcted treated with the TH group (MI\u00a0+\u00a0TH), and infarcted co-treated with the carvedilol and TH group (MI\u00a0+\u00a0C\u00a0+\u00a0TH). Haemodynamic analysis was assessed 15 days post-AMI. The left ventricle (LV) was collected for morphometric and Western blot analysis. The MI group presented LV systolic pressure reduction, LV end-diastolic pressure elevation, and contractility index decrease compared to the SHAM group. The MI\u00a0+\u00a0C, MI\u00a0+\u00a0TH, and MI\u00a0+\u00a0C\u00a0+\u00a0TH groups did not reveal such alterations compared to the SHAM group. The MI\u00a0+\u00a0TH and MI\u00a0+\u00a0C\u00a0+\u00a0TH groups presented reduced MyD88 and NLRP3 and increased HIF-1\u03b1 levels. In conclusion, all treatments preserve the cardiac haemodynamic, and only TH, as isolated treatment or in co-treatment with carvedilol, was able to reduce MyD88 and NLRP3 and increase HIF-1\u03b1 in the infarcted heart. <\/jats:p>","DOI":"10.1139\/cjpp-2022-0355","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T12:00:49Z","timestamp":1674216049000},"page":"106-116","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1\u03b1 in the infarcted heart"],"prefix":"10.1139","volume":"101","author":[{"given":"Vanessa Duarte","family":"Ortiz","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Department of Physiology, Institute of Basic Health Science, Federal University of Rio Grande do Sul","place":["Porto Alegre, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rayane Brinck","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Department of Physiology, Institute of Basic Health Science, Federal University of Rio Grande do Sul","place":["Porto Alegre, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"T\u00fcrck","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Department of Physiology, Institute of Basic Health Science, Federal University of Rio Grande do Sul","place":["Porto Alegre, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giana Blume","family":"Corssac","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Department of Physiology, Institute of Basic Health Science, Federal University of Rio Grande do Sul","place":["Porto Alegre, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane","family":"Bell\u00f3-Klein","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Department of Physiology, Institute of Basic Health Science, Federal University of Rio Grande do Sul","place":["Porto Alegre, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Luz","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Department of Physiology, Institute of Basic Health Science, Federal University of Rio Grande do Sul","place":["Porto Alegre, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9482-7388","authenticated-orcid":false,"given":"Alex Sander da Rosa","family":"Araujo","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Department of Physiology, Institute of Basic Health Science, Federal University of Rio Grande do Sul","place":["Porto Alegre, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.02.005"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.033"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04560-8"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.04.010"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-015-1204-3"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.09.003"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2020.1779752"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765202020190658"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243196"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2015.12.004"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.614030"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-008-9125-7"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.11909\/j.issn.1671-5411.2015.03.020"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2016.05.004"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243162"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150006"},{"issue":"1","key":"refg17\/ref17","first-page":"291","volume":"148","author":"Hill M.F.","year":"1996","journal-title":"Am. 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