{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:56:12Z","timestamp":1771030572037,"version":"3.50.1"},"reference-count":38,"publisher":"Canadian Science Publishing","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"funder":[{"name":"Herminio Ometto Foundation","award":["FHO (001)"],"award-info":[{"award-number":["FHO (001)"]}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p> Renovascular hypertension (RHV) is the cause of high blood pressure due to left renal ischemia, and obesity and hypertension cause an inflammatory response. This work analyzed the inflammatory and tissue repair profile in renal, hepatic, and cardiac tissues in an animal model of RVH associated with a high-fat diet and caloric restriction. The expressions of ROR\u03b3-t, IL-17, T-bet, and TNF-\u03b1 decreased and IFN-\u03b3 increased in the right kidney. In relation to the left kidney, caloric restriction decreased the expression of IFN-\u03b3. In the liver, caloric restriction decreased ROR\u03b3-t, IL-17, and T-bet. Hypertension associated with obesity decreased the expression of IFN-\u03b3, while caloric restriction increased. In the right kidney, hypertension and obesity, associated or not with caloric restriction, increased the area of collagen fibers. In the heart and liver, caloric restriction reduced the area of collagen fibers. Caloric restriction increased vascular endothelial growth factor, reduced levels of growth transformation factor-\u03b21 (TGF-\u03b2), and increased collagen I in the left kidney. Hypertension\/obesity, submitted or not having caloric restriction, increased TGF-\u03b2 in liver. The results suggest that caloric restriction has beneficial effects in lowering blood pressure and regulating tissue proinflammatory cytokines. However, there was no change in the structure and composition of tissue repair markers. <\/jats:p>","DOI":"10.1139\/cjpp-2022-0452","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:00:18Z","timestamp":1695639618000},"page":"661-671","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension"],"prefix":"10.1139","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-8928","authenticated-orcid":false,"given":"Thayane Rafaela Feola","family":"Pizzo","sequence":"first","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Valverde","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Eduardo","family":"Orzari","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Gustavo","family":"Terciotti","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robson Damasceno","family":"de Lima","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Russo","family":"Costa do Bomfim","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Augusto Marreto","family":"Esquisatto","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Ant\u00f4nio Moretti","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-2202","authenticated-orcid":false,"given":"Maria Esm\u00e9ria","family":"Corezola do Amaral","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Andrea","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00edra","family":"Felonato","sequence":"additional","affiliation":[{"name":"Graduate Program of Biomedical Sciences, University Center of Herminio Ometto Foundation\u2014FHO","place":["Araras, Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200104000-00003"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i8.855"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2013-0069"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0795-1"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-0947-2_21"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.44"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010274"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2014.2"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.17.4.642"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19071864"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.08.045"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00370"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-012-0242-z"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.a2019.0008"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2013.16.3.143"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2649"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.145094"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303697"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.04.005"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-019-0971-6"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1221-6"},{"key":"refg22\/ref22","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0283"},{"key":"refg23\/ref23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030751"},{"key":"refg24\/ref24","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.22590v2"},{"key":"refg25\/ref25","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1098"},{"key":"refg26\/ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0842-6"},{"key":"refg27\/ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefro.2020.11.009"},{"key":"refg28\/ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-015-0234-6"},{"key":"refg29\/ref29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-030387"},{"key":"refg30\/ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9365-4"},{"key":"refg31\/ref31","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1021-18"},{"key":"refg32\/ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.10.007"},{"key":"refg33\/ref33","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00645.2011"},{"key":"refg34\/ref34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114895"},{"key":"refg35\/ref35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00179.2013"},{"key":"refg36\/ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.04.013"},{"key":"refg37\/ref37","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03863"},{"key":"refg38\/ref38","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3172"}],"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/full-xml\/10.1139\/cjpp-2022-0452","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2022-0452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:08:49Z","timestamp":1751468929000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2022-0452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,1]]}},"alternative-id":["10.1139\/cjpp-2022-0452"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2022-0452","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]},"assertion":[{"value":"2023-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}