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The study aimed to investigate the therapeutic role of decorin on cardiac function in a rat model of myocardial infarction. Thirty adult male Wistar rats were divided into control group\u2014rats were subcutaneously injected with normal saline, isoprenaline-injected group\u2014rats were subcutaneously injected with isoprenaline (85\u2009mg\/kg) once daily for 2\u2009days to induce myocardial infarction, and decorin\u2009\u00b1\u2009isoprenaline-injected group\u2014rats were injected as the previous group, followed by decorin injection (0.1\u2009mg\/kg) once daily for 7\u2009days. Cardiac hemodynamics, serum lactate dehydrogenase (LDH), creatine kinase\u2013MB (CK\u2013MB), oxidative stress markers, gene expression for myocardial-transforming growth factor beta 1 (TGF-\u03b21), interleukin 1 b (IL-1\u03b2), tumor necrosis factor alpha (TNF-\u03b1), and cardiac caspase-3 immunohistochemical analysis were done. Isoprenaline\u2009+\u2009decorin group had significant improvement in cardiac hemodynamics and oxidative stress markers; significant decrease in serum CK\u2013MB, LDH, and myocardial gene expression for TNF-\u03b1, IL-1\u03b2, and TGF-\u03b21; and decreased cardiac caspase-3 immunoreactivity was present. Therefore, decorin can be used as a therapeutic agent after myocardial infarction as it improved the cardiac function. <\/jats:p>","DOI":"10.1139\/cjpp-2022-0482","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T21:36:25Z","timestamp":1678829785000},"page":"286-293","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction"],"prefix":"10.1139","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5659-1610","authenticated-orcid":false,"given":"Ghida Mohamed","family":"Hassan","sequence":"first","affiliation":[{"name":"Physiology Department, Faculty of Medicine, Ain Shams University","place":["Cairo, Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham Hassan","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"Physiology Department, Faculty of Medicine, Zagazig University","place":["Zagazig, Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.740233"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2011.22069"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1606915"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.005"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412438104"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.08.228"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016423"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.419366"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.10.002"},{"key":"refg10\/ref10","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070974"},{"key":"refg11\/ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63154-9"},{"key":"refg12\/ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(00)80018-7"},{"key":"refg13\/ref13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224251"},{"key":"refg14\/ref14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00053.2004"},{"key":"refg15\/ref15","doi-asserted-by":"publisher","DOI":"10.1258\/002367793780745471"},{"key":"refg16\/ref16","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12145"},{"key":"refg17\/ref17","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25153426"},{"key":"refg18\/ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"refg19\/ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.10.002"},{"key":"refg20\/ref20","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00140"},{"key":"refg21\/ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.07.017"},{"issue":"04","key":"refg22\/ref22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1055\/s-0039-1679104","volume":"3","author":"Jacob R.","year":"2018","journal-title":"Indian J. 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