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GLP-1RAs also have anti-inflammatory and antioxidative effects and can improve cardiac function. The aim of this study was to investigate the cardioprotective effects of liraglutide, a GLP-1RA, on isoprenaline-induced myocardial injury in rats. The study included four groups of animals. They were pretreated with saline for 10\u2009days\u2009+\u2009saline on days\u20099 and 10 (control), saline for 10\u2009days\u2009+\u2009isoprenaline on days\u20099 and 10 (isoprenaline group), liraglutide for 10\u2009days\u2009+\u2009saline on days\u20099 and 10 (liraglutide group), and liraglutide for 10\u2009days, and on days\u20099 and 10 isoprenaline was administered. This study evaluated ECG, myocardial injury markers, oxidative stress markers, and pathohistological changes. The results showed that liraglutide mitigated the isoprenaline-induced cardiac dysfunction recorded by ECG. Liraglutide reduced serum markers of myocardial injury such as high-sensitive troponin I, aspartate aminotransferase, alanine aminotransferase, reduced thiobarbituric acid reactive substances, increased catalase and superoxide dismutase activity, increased reduced glutathione level, and improved lipid profile. Liraglutide induced antioxidative protection and alleviated isoprenaline-induced myocardial injury. <\/jats:p>","DOI":"10.1139\/cjpp-2022-0534","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T16:36:50Z","timestamp":1677515810000},"page":"258-267","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats"],"prefix":"10.1139","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-1721","authenticated-orcid":false,"given":"Zorislava","family":"Bajic","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Banja Luka","place":["78000 Banja Luka, Bosnia and Herzegovina"]},{"name":"Centre for Biomedical Research, Faculty of Medicine, University of Banja Luka","place":["78000 Banja Luka, Bosnia and 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