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Pharmacol."],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p> This work evaluated the combined effects of alpha-lipoic acid (ALA) and ischemic postconditioning (Post) on myocardial infarction and cell death in rats with chronic type-II diabetes following ischemia\/reperfusion injury. The rats received a high-fat diet and were given one intraperitoneal injection of 35\u2009mg\/kg streptozotocin to induce chronic diabetes. They were then pretreated with ALA (100\u2009mg\/kg\/day, orally) for 5\u2009weeks before undergoing ischemia\/reperfusion (I\/R) insult. The hearts experienced 35\u2009min regional ischemia through ligating the left anterior descending coronary artery, followed by 60\u2009min reperfusion. The Post protocol involved 6 cycles of a 10\/10\u2009s algorithm, applied during the early stage of reperfusion. The use of Post alone did not significantly alter lactate dehydrogenase and infarct size levels, while ALA showed positive effects. Similar findings were observed for apoptotic changes with single treatments. However, the concurrent administration of ALA and Post significantly reduced the protein expressions of Bax, Bax\/Bcl2, and cleaved caspase-3 while increasing Bcl2 expression. Additionally, the histopathological findings of the combined therapy were superior to those of single treatments. The concomitant use of ALA and Post effectively inhibited apoptosis, leading to cardiac recovery after I\/R injury in diabetic conditions. This strategy could improve outcomes for preserving diabetic hearts following I\/R insults. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0044","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T21:38:02Z","timestamp":1690839482000},"page":"682-691","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia\/reperfusion injury"],"prefix":"10.1139","volume":"101","author":[{"given":"Sanaz","family":"Gholami","sequence":"first","affiliation":[{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences","place":["Tabriz, Islamic Republic of Iran"]},{"name":"Student Research Committee, Tabriz University of Medical Sciences","place":["Tabriz, Islamic Republic of Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8092-7820","authenticated-orcid":false,"given":"Reza","family":"Badalzadeh","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center, Tabriz University of Medical Sciences","place":["Tabriz, Islamic Republic of Iran"]},{"name":"Faculty of Medicine, Tabriz University of Medical Sciences","place":["Tabriz, Islamic Republic of Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Alihemmati","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center, Tabriz University of Medical Sciences","place":["Tabriz, Islamic Republic of Iran"]},{"name":"Faculty of Medicine, Tabriz University of Medical Sciences","place":["Tabriz, Islamic Republic of Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.04.010"},{"key":"refg2\/ref2","doi-asserted-by":"crossref","first-page":"112772","DOI":"10.1016\/j.biopha.2022.112772","volume":"148","author":"Babes E.E.","year":"2022","journal-title":"Biomed. 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