{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:56:56Z","timestamp":1790279816042,"version":"4.1.0"},"reference-count":46,"publisher":"Canadian Science Publishing","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.en_GB"}],"funder":[{"name":"High level Talents Project of Hainan Natural Science Foundation of 2022","award":["822RC826"],"award-info":[{"award-number":["822RC826"]}]},{"name":"Hainan Health industry scientific research project of 2021","award":["21A200073"],"award-info":[{"award-number":["21A200073"]}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p> Diabetic nephropathy is one of the microvascular complications of diabetes. This study is aimed at investigating the role and mechanisms of salvianolic acid B (Sal B) in diabetic nephropathy. High glucose (HG)-induced human renal tubular epithelial HK-2 cells were treated with Sal B, BAY-60-6583 (agonist of adenosine 2B receptor), or PSB-603 (antagonist of adenosine 2B receptor) for 24 h. Adenosine A2b receptor (ADORA2B), NACHT, leucine-rich repeat (LRR), and pyrin (PYD) domains-containing protein 3 (NALP3), and nuclear factor Kappa B (NF\u03baB) expressions, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) levels were examined. Following 6 weeks of Sal B treatment, db\/db mice blood and kidney tissue were harvested for biochemical detection with hematoxylin\u2013eosin (H&amp;E), Masson\u2019s, periodic acid schiff (PAS), and Sirius red staining and detection of ADORA2B, NALP3, NF\u03baB, interleukin 1\u03b2 (IL-1\u03b2), and toll-like receptor 4 (TLR4) activity. NF\u03baB, NALP3, and ADORA2B were found to be downregulated in Sal B treated HK-2 cells exposed to high glucose (HG), accompanied by elevated levels of MMPs and reduced intracellular ROS production. Sal B-treated diabetic mice had the improvement in body weight, water intake, hyperglycemia, hyperlipidemia, and liver and kidney function. Altogether, Sal B attenuates HG-induced kidney tubule cell injury and diabetic nephropathy in diabetic mice, providing clues to other novel mechanisms by which Sal B is beneficial in diabetic nephropathy. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0089","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T21:34:41Z","timestamp":1702157681000},"page":"318-330","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NF\u03baB activity"],"prefix":"10.1139","volume":"102","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Practice, The First Affiliated Hospital of Hainan Medical University","place":["Haikou, 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