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Female Wistar rats (8-week-old) were randomly allocated into four groups of n\u2009=6\/group, which received vehicle, sodium acetate (200\u2009mg), letrozole (1\u2009mg\/kg), and letrozole plus sodium acetate, respectively. The animals were treated by oral gavage, once daily for a period of 21\u2009days. The PCOS animals were insulin-resistant, hyperandrogenic, and hypoestrogenic with decreased sex-hormone binding globulin. In addition, the hepatic tissue had increased lipid profile and decreased glycogen synthesis, while the adipose tissue showed decreased lipid profile with elevated glycogen synthesis. Besides, the results also showed increased malondialdehyde, \u03b3-glutamyl transferase, lactate dehydrogenase, and inflammatory mediators with corresponding decrease in antioxidant defense in the hepatic and adipose tissues. Immunohistochemical evaluation also demonstrated severe expression with Bcl2-associated X protein\/NLRP3 antibodies. Nonetheless, concomitant acetate supplementation attenuated these derangements. The present data collectively suggest that acetate ameliorates adipose\u2013hepatic glycolipid dysregulation in experimental PCOS model by attenuating androgen excess and NF-\u03baB\/NLRP3 immunoreactivity. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0169","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T21:40:01Z","timestamp":1692308401000},"page":"630-641","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Alleviation of adipose\u2013hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-\u03baB\/NLRP3 repression"],"prefix":"10.1139","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-9688","authenticated-orcid":false,"given":"Kehinde S.","family":"Olaniyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie E.","family":"Areloegbe","sequence":"additional","affiliation":[{"name":"Cardio\/Endo-metabolic and Microbiome Research Unit, Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University","place":["Ado-Ekiti, Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11891"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2013.12.001"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2021.100085"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.07.053"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.10.001"},{"key":"refg6\/ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"refg7\/ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2021.105829"},{"key":"refg8\/ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab232.224"},{"key":"refg9\/ref9","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170987"},{"issue":"4","key":"refg10\/ref10","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1210\/jc.2005-2327","volume":"91","author":"Gonz\u00e1lez F.","year":"2006","journal-title":"J. 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