{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:07:58Z","timestamp":1773295678093,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Science Publishing","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"abstract":"<jats:p> Phototherapy is the standard treatment for neonatal jaundice. We aimed to review the efficacy and safety of fenofibrate as an adjunct therapy. Twelve databases were searched and a systematic review and meta-analysis were conducted. Mean change (MC), mean difference (MD), and risk ratios (RR) with a 95% confidence interval (CI) were calculated using a random effects model. The GRADE approach was used to evaluate the evidence's certainty. Nine randomized trials were included. The MC of total serum bilirubin (mg\/dl) (TSB) was significant at 12, 24, 36, 48 and 72 hours with respective MC (95% CI) values of -0.46 (-0.61, -0.310), -1.10 (-1.68, -0.52), -2.06 (-2.20, -1.91), -2.15 (-2.74, -1.56), and -1.13 (-1.71, -0.55). The FEN+PT group had a shorter duration of phototherapy (MD -14.36 hours; 95% CI -23.67, -5.06) and a shorter hospital stay (MD: -1.40 days; 95% CI: -2.14, -0.66). There was no significant difference in the risk of complications (RR: 0.89; 95% CI: 0.54, 1.46) or the need for exchange transfusion (RR: 0.58; 95% CI: 0.12, 2.81). The certainty of the evidence was very low for all outcomes. In conclusion, fenofibrate might be a safe adjunct to neonatal phototherapy. Larger RCTs are needed for confirmation of these results. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0213","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T21:35:46Z","timestamp":1701120946000},"source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of fenofibrate in combination with phototherapy for the treatment of neonatal hyperbilirubinemia: A systematic review and meta-analyses."],"prefix":"10.1139","author":[{"given":"Mohammed","family":"Abdellatif","sequence":"first","affiliation":[{"name":"Starcare Hospital, 430304, Seeb, Muscat, Oman;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Ahmed Fouad","family":"Abozaid","sequence":"additional","affiliation":[{"name":"Ain Shams University, 68791, Cairo, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakesh S","family":"Shah","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital and University of Toronto, Toronto, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nacir","family":"Dhouibi","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar, 37964, Tunis, Tunisia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuan","family":"Nguyen-Khac","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Ho Chi Minh City Hospital, 377386, Ho Chi Minh City, Viet Nam;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafeef","family":"Khleif","sequence":"additional","affiliation":[{"name":"Xavier University School of Medicine, 101684, Oranjestad, Aruba;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Ngoc","family":"Luu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Ho Chi Minh City Hospital, 377386, Ho Chi Minh City, Viet Nam;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinh Kim","family":"Quyen","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Ho Chi Minh City Hospital, 377386, Ho Chi Minh City, Viet Nam;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Mohareb","sequence":"additional","affiliation":[{"name":"Aswan University, 435387, Sahary, Aswan, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladson","family":"Vaghela","sequence":"additional","affiliation":[{"name":"GMERS Medical College and Hospital, 379603, Gandhinagar, Gujarat, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshan Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Shadan Institute of Medical Sciences, 78401, Hyderabad, Telangana, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang Nhat","family":"Pham","sequence":"additional","affiliation":[{"name":"University of Milan, 9304, Milano, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelrahman M","family":"Makram","sequence":"additional","affiliation":[{"name":"Imperial College London, 4615, London, London, United Kingdom of Great Britain and Northern Ireland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Tien","family":"Huy","sequence":"additional","affiliation":[{"name":"Nagasaki University School of Tropical Medicine and Global Health, 598388, Nagasaki, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","published-online":{"date-parts":[[2023,11,27]]},"container-title":["Canadian Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdnsciencepub.com\/doi\/pdf\/10.1139\/cjpp-2023-0213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T21:35:48Z","timestamp":1701120948000},"score":1,"resource":{"primary":{"URL":"https:\/\/cdnsciencepub.com\/doi\/10.1139\/cjpp-2023-0213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":0,"alternative-id":["10.1139\/cjpp-2023-0213"],"URL":"https:\/\/doi.org\/10.1139\/cjpp-2023-0213","relation":{},"ISSN":["0008-4212","1205-7541"],"issn-type":[{"value":"0008-4212","type":"print"},{"value":"1205-7541","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"article-number":"cjpp-2023-0213"}}