{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:44Z","timestamp":1790957684088,"version":"4.1.0"},"reference-count":43,"publisher":"Canadian Science Publishing","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"funder":[{"name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","award":["451-03-68\/2023-14\/200113"],"award-info":[{"award-number":["451-03-68\/2023-14\/200113"]}]}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:p> Long-term exposure to amiodarone, an antiarrhythmic drug, can induce different organ damage, including liver. Cell damage included by amiodarone is a consequence of mitochondrial damage, reactive oxygen species production, and cell energy depletion leading to programmed cell death. In the present study, hepatoprotective potential of neurohormone melatonin (50\u00a0mg\/kg\/day) was evaluated in a chronic experimental model of liver damage induced by a 4-week application of amiodarone (70\u00a0mg\/kg\/day). The obtained results indicate that amiodarone induces an increase in xanthine oxidase activity, as well as the content of the lipid and protein oxidatively modified products and p53 levels. Microscopic analysis further corroborated the biochemical findings revealing hepatocyte degeneration, apoptosis, and occasional necrosis, with the activation of Kupffer cells. Coadministration of melatonin and amiodaron prevented an increase in certain damage associated parameters, due to its multiple targets. In conclusion, the application of melatonin together with amiodarone prevented an increase in tissue oxidative damage parameters and moderately prevented liver cell apoptosis, indicating that the damage of hepatocytes provoked by amiodarone supersedes the protective properties of melatonin in a given dose. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0253","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T21:37:50Z","timestamp":1702330670000},"page":"374-382","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of melatonin in preventing amiodarone-induced rat liver damage"],"prefix":"10.1139","volume":"102","author":[{"given":"Dejan","family":"Petrovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Institute for Treatment and Rehabilitation, University of Ni\u0161","place":["Ni\u0161ka Banja, Ni\u0161, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Deljanin","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Treatment and Rehabilitation, University of Ni\u0161","place":["Ni\u0161ka Banja, Ni\u0161, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Simonovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Treatment and Rehabilitation, University of Ni\u0161","place":["Ni\u0161ka Banja, Ni\u0161, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milovan","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Treatment and Rehabilitation, University of Ni\u0161","place":["Ni\u0161ka Banja, Ni\u0161, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Stankovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Clinical Centre Ni\u0161","place":["Ni\u0161, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavi\u0161a","family":"Stani\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gyanaecology, Faculty of Medicine, University of Pristina","place":["Kosovska Mitrovica, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute for Treatment and Rehabilitation, University of Ni\u0161","place":["Ni\u0161ka Banja, Ni\u0161, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neboj\u0161a","family":"Arsi\u0107","sequence":"additional","affiliation":[{"name":"Dom zdravlja Medve\u0111a","place":["16240 Medve\u0111a, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-6428","authenticated-orcid":false,"given":"Du\u0161an T.","family":"Sokolovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Ni\u0161","place":["Ni\u0161, Serbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6265853"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-4274(98)00097-6"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24385"},{"key":"refg4\/ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.11.6995"},{"key":"refg5\/ref5","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12264"},{"key":"refg6\/ref6","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0022-3565(25)22984-6","volume":"255","author":"Fromenty B.","year":"1990","journal-title":"J. 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