{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:52:21Z","timestamp":1778770341480,"version":"3.51.4"},"reference-count":23,"publisher":"Canadian Science Publishing","issue":"01","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.nrcresearchpress.com\/page\/about\/CorporateTextAndDataMining"}],"funder":[{"name":"The Department of Medical Laboratory Sciences at Arab American University at Palestine"},{"name":"The Department of Chemistry at Alquds University at Palestine"}],"content-domain":{"domain":["cdnsciencepub.com"],"crossmark-restriction":false},"short-container-title":["Can. J. Physiol. Pharmacol."],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:p> Hedera helix L., a member of the Araliaceae family, is a commonly known decorative plant with recognized medicinal activities. In this study, the ethanolic extract from H. helix leaves was investigated for its total polyphenolic and flavonoid contents, as well as its antioxidant and antibacterial properties. The aim was to evaluate its potential for controlling certain infections by screening its antibacterial activity against selected pathogenic bacteria. The total phenolic and flavonoid contents of the extract were determined using colorimetric methods. The antioxidant activity was assessed through two assay methods: the 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity and the reducing power ferric reducing\/antioxidant power (FRAP). The antibacterial activity against different pathogenic bacteria, including Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa, was evaluated using the well diffusion method. The total phenolic and flavonoid contents of the H. helix extract were found to be 134.3\u00a0\u00b1\u00a04.9\u00a0mg gallic acid\/g and 42.4\u00a0\u00b1\u00a03.6\u00a0mg catechin\/g, respectively. The extract exhibited antioxidant activity, with a reducing power represented by an FRAP value of 9.5\u00a0\u00b1\u00a00.9\u00a0mmol Fe<jats:sup>+2<\/jats:sup>\/g DW and a percentage inhibition of DPPH of 64.7\u00a0\u00b1\u00a03.8 at 80\u00a0\u00b5g\/mL. The extract demonstrated antibacterial activity, inhibiting the growth of K. pneumoniae and S. aureus with zone of inhibition values of 18.5 and 23.2\u00a0mm, respectively, using 25\u00a0mg\/well. However, E.\u00a0coli and P. aeruginosa exhibited resistance to the extract. The findings of this study highlight the antibacterial and antioxidant properties of the ethanolic extract from H. helix leaves. The extract exhibited significant phenolic and flavonoid contents, as well as antioxidant activity. It also demonstrated antibacterial activity against selected pathogenic bacteria, suggesting its potential for controlling certain infections. Further research is warranted to identify the active compounds responsible for these activities and to explore their mechanisms of action. <\/jats:p>","DOI":"10.1139\/cjpp-2023-0264","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:02:13Z","timestamp":1697626933000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1139\/csp-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Unveiling the antibacterial and antioxidant potential of <i>Hedera helix<\/i> leaf extracts: recent findings"],"prefix":"10.1139","volume":"102","author":[{"given":"Khaled","family":"Qabaha","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences","place":["Jenin, Palestine"]},{"name":"Arab American University","place":["Jenin, Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jehad","family":"Abbadi","sequence":"additional","affiliation":[{"name":"Biology Department, Faculty of Science and Technology, Al-Quds University","place":["Jerusalem, Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Yaghmour","sequence":"additional","affiliation":[{"name":"Biology Department, Faculty of Science and Technology, Al-Quds University","place":["Jerusalem, Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thameen","family":"Hijawi","sequence":"additional","affiliation":[{"name":"Institute of Development Studies, Al-Quds University","place":["Jerusalem, Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-4527","authenticated-orcid":false,"given":"Saleh A.","family":"Naser","sequence":"additional","affiliation":[{"name":"Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando","place":["FL, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuad","family":"Al-Rimawi","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science and Technology","place":["Palestine"]},{"name":"Al-Quds University","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"155","reference":[{"key":"refg1\/ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2005.03.003"},{"key":"refg2\/ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99005-5"},{"key":"refg3\/ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.06.014"},{"key":"refg4\/ref4","first-page":"770","volume":"59","author":"Demirci B.","year":"2004","journal-title":"Die Pharm. 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